2eos: Difference between revisions
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==Solution structure of the C2H2 type zinc finger (region 626-654) of human B-cell lymphoma 6 protein== | ==Solution structure of the C2H2 type zinc finger (region 626-654) of human B-cell lymphoma 6 protein== | ||
<StructureSection load='2eos' size='340' side='right'caption='[[2eos | <StructureSection load='2eos' size='340' side='right'caption='[[2eos]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2eos]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2eos]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EOS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EOS FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2eos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eos OCA], [https://pdbe.org/2eos PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2eos RCSB], [https://www.ebi.ac.uk/pdbsum/2eos PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2eos ProSAT], [https://www.topsan.org/Proteins/RSGI/2eos TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2eos FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eos OCA], [https://pdbe.org/2eos PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2eos RCSB], [https://www.ebi.ac.uk/pdbsum/2eos PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2eos ProSAT], [https://www.topsan.org/Proteins/RSGI/2eos TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
[https://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN] Note=Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t(3;14)(q27;q32); translocation t(3;22)(q27;q11) with immunoglobulin gene regions. Note=A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with POU2AF1/OBF1. Note=A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t(3;4)(q27;p11) with ARHH/TTF. | |||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/BCL6_HUMAN BCL6_HUMAN] Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis.<ref>PMID:9649500</ref> <ref>PMID:18280243</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Abe | [[Category: Abe H]] | ||
[[Category: Kigawa | [[Category: Kigawa T]] | ||
[[Category: Kobayashi | [[Category: Kobayashi N]] | ||
[[Category: Koshiba | [[Category: Koshiba S]] | ||
[[Category: Li | [[Category: Li H]] | ||
[[Category: Saito K]] | |||
[[Category: Saito | [[Category: Sato M]] | ||
[[Category: Sato | [[Category: Tochio N]] | ||
[[Category: Tochio | [[Category: Tomizawa T]] | ||
[[Category: Tomizawa | [[Category: Yokoyama S]] | ||
[[Category: Yokoyama | |||
Latest revision as of 18:53, 29 May 2024
Solution structure of the C2H2 type zinc finger (region 626-654) of human B-cell lymphoma 6 protein
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