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==Solution structure of the 11th C2H2 type zinc finger domain of Zinc finger protein 224==
==Solution structure of the 11th C2H2 type zinc finger domain of Zinc finger protein 224==
<StructureSection load='2eq4' size='340' side='right'caption='[[2eq4]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2eq4' size='340' side='right'caption='[[2eq4]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2eq4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EQ4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EQ4 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2eq4]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2EQ4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2EQ4 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">ZNF224, BMZF2, KOX22, ZNF233, ZNF255, ZNF27 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2eq4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eq4 OCA], [https://pdbe.org/2eq4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2eq4 RCSB], [https://www.ebi.ac.uk/pdbsum/2eq4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2eq4 ProSAT], [https://www.topsan.org/Proteins/RSGI/2eq4 TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2eq4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2eq4 OCA], [https://pdbe.org/2eq4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2eq4 RCSB], [https://www.ebi.ac.uk/pdbsum/2eq4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2eq4 ProSAT], [https://www.topsan.org/Proteins/RSGI/2eq4 TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/ZN224_HUMAN ZN224_HUMAN]] May be involved in transcriptional regulation as a transcriptional repressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells.<ref>PMID:20587513</ref>
[https://www.uniprot.org/uniprot/ZN224_HUMAN ZN224_HUMAN] May be involved in transcriptional regulation as a transcriptional repressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells.<ref>PMID:20587513</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Inoue, M]]
[[Category: Inoue M]]
[[Category: Kigawa, T]]
[[Category: Kigawa T]]
[[Category: Masuda, K]]
[[Category: Masuda K]]
[[Category: Muto, Y]]
[[Category: Muto Y]]
[[Category: Structural genomic]]
[[Category: Shirouzu M]]
[[Category: Shirouzu, M]]
[[Category: Suzuki S]]
[[Category: Suzuki, S]]
[[Category: Terada T]]
[[Category: Terada, T]]
[[Category: Yokoyama S]]
[[Category: Yokoyama, S]]
[[Category: C2h2]]
[[Category: National project on protein structural and functional analyse]]
[[Category: Nppsfa]]
[[Category: Rsgi]]
[[Category: Transcription]]
[[Category: Zinc finger domain]]
Retrieved from "https://proteopedia.org/2eq4"