2htf: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
 
Line 1: Line 1:


==The solution structure of the BRCT domain from human polymerase reveals homology with the TdT BRCT domain==
==The solution structure of the BRCT domain from human polymerase reveals homology with the TdT BRCT domain==
<StructureSection load='2htf' size='340' side='right'caption='[[2htf]], [[NMR_Ensembles_of_Models | 11 NMR models]]' scene=''>
<StructureSection load='2htf' size='340' side='right'caption='[[2htf]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2htf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HTF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HTF FirstGlance]. <br>
<table><tr><td colspan='2'>[[2htf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HTF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HTF FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">POLM ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2htf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2htf OCA], [https://pdbe.org/2htf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2htf RCSB], [https://www.ebi.ac.uk/pdbsum/2htf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2htf ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2htf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2htf OCA], [https://pdbe.org/2htf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2htf RCSB], [https://www.ebi.ac.uk/pdbsum/2htf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2htf ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/DPOLM_HUMAN DPOLM_HUMAN]] Gap-filling polymerase involved in repair of DNA double-strand breaks by non-homologous end joining (NHEJ). Participates in immunoglobulin (Ig) light chain gene rearrangement in V(D)J recombination.<ref>PMID:12640116</ref> <ref>PMID:12888504</ref> <ref>PMID:17483519</ref> <ref>PMID:17915942</ref>
[https://www.uniprot.org/uniprot/DPOLM_HUMAN DPOLM_HUMAN] Gap-filling polymerase involved in repair of DNA double-strand breaks by non-homologous end joining (NHEJ). Participates in immunoglobulin (Ig) light chain gene rearrangement in V(D)J recombination.<ref>PMID:12640116</ref> <ref>PMID:12888504</ref> <ref>PMID:17483519</ref> <ref>PMID:17915942</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 29: Line 28:
</div>
</div>
<div class="pdbe-citations 2htf" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 2htf" style="background-color:#fffaf0;"></div>
==See Also==
*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: DNA-directed DNA polymerase]]
[[Category: Homo sapiens]]
[[Category: Human]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Clarkson, M W]]
[[Category: Clarkson MW]]
[[Category: DeRose, E F]]
[[Category: DeRose EF]]
[[Category: Gilmore, S A]]
[[Category: Gilmore SA]]
[[Category: Lee, A L]]
[[Category: Lee AL]]
[[Category: London, R E]]
[[Category: London RE]]
[[Category: Mueller, G A]]
[[Category: Mueller GA]]
[[Category: Ramsden, D A]]
[[Category: Ramsden DA]]
[[Category: Alpha-beta-alpha sandwich]]
[[Category: Brct domain]]
[[Category: Transferase]]
Retrieved from "https://proteopedia.org/2htf"