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==Solution structure of the RRM domain of SR rich factor 9G8==
==Solution structure of the RRM domain of SR rich factor 9G8==
<StructureSection load='2hvz' size='340' side='right'caption='[[2hvz]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2hvz' size='340' side='right'caption='[[2hvz]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2hvz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HVZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HVZ FirstGlance]. <br>
<table><tr><td colspan='2'>[[2hvz]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2HVZ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2HVZ FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SFRS7 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hvz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hvz OCA], [https://pdbe.org/2hvz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hvz RCSB], [https://www.ebi.ac.uk/pdbsum/2hvz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hvz ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2hvz FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2hvz OCA], [https://pdbe.org/2hvz PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2hvz RCSB], [https://www.ebi.ac.uk/pdbsum/2hvz PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2hvz ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/SRSF7_HUMAN SRSF7_HUMAN]] Required for pre-mRNA splicing. Can also modulate alternative splicing in vitro. Represses the splicing of MAPT/Tau exon 10. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. RNA-binding is semi-sequence specific.<ref>PMID:11336712</ref> <ref>PMID:12667464</ref> <ref>PMID:15009664</ref> <ref>PMID:18364396</ref>
[https://www.uniprot.org/uniprot/SRSF7_HUMAN SRSF7_HUMAN] Required for pre-mRNA splicing. Can also modulate alternative splicing in vitro. Represses the splicing of MAPT/Tau exon 10. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. RNA-binding is semi-sequence specific.<ref>PMID:11336712</ref> <ref>PMID:12667464</ref> <ref>PMID:15009664</ref> <ref>PMID:18364396</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Golovanov, A P]]
[[Category: Golovanov AP]]
[[Category: Hautbergue, G M]]
[[Category: Hautbergue GM]]
[[Category: Lian, L Y]]
[[Category: Lian LY]]
[[Category: Tintaru, A M]]
[[Category: Tintaru AM]]
[[Category: Wilson, S A]]
[[Category: Wilson SA]]
[[Category: Rna binding protein]]
[[Category: Rrm]]
Retrieved from "https://proteopedia.org/2hvz"