2i50: Difference between revisions

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==Solution Structure of Ubp-M Znf-UBP domain==
==Solution Structure of Ubp-M Znf-UBP domain==
<StructureSection load='2i50' size='340' side='right'caption='[[2i50]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='2i50' size='340' side='right'caption='[[2i50]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2i50]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I50 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I50 FirstGlance]. <br>
<table><tr><td colspan='2'>[[2i50]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I50 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I50 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">USP16 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Ubiquitin_thiolesterase Ubiquitin thiolesterase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.2.15 3.1.2.15] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i50 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i50 OCA], [https://pdbe.org/2i50 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i50 RCSB], [https://www.ebi.ac.uk/pdbsum/2i50 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i50 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i50 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i50 OCA], [https://pdbe.org/2i50 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i50 RCSB], [https://www.ebi.ac.uk/pdbsum/2i50 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i50 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[https://www.uniprot.org/uniprot/UBP16_HUMAN UBP16_HUMAN]] Note=A chromosomal aberration involving USP16 is a cause of Chronic myelomonocytic leukemia. Inversion inv(21) (q21;q22) with RUNX1/AML1.  
[https://www.uniprot.org/uniprot/UBP16_HUMAN UBP16_HUMAN] Note=A chromosomal aberration involving USP16 is a cause of Chronic myelomonocytic leukemia. Inversion inv(21) (q21;q22) with RUNX1/AML1.
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/UBP16_HUMAN UBP16_HUMAN]] Specifically deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-10' of histone H3, and is required for chromosome segregation when cells enter into mitosis. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.<ref>PMID:10077596</ref> <ref>PMID:11753566</ref> <ref>PMID:17914355</ref>
[https://www.uniprot.org/uniprot/UBP16_HUMAN UBP16_HUMAN] Specifically deubiquitinates histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-10' of histone H3, and is required for chromosome segregation when cells enter into mitosis. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.<ref>PMID:10077596</ref> <ref>PMID:11753566</ref> <ref>PMID:17914355</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Ubiquitin thiolesterase]]
[[Category: Pai M-T]]
[[Category: Pai, M T]]
[[Category: Alpha/beta zinc-finger]]
[[Category: Hydrolase]]
[[Category: Metalloprotein]]
[[Category: Ring-finger]]
[[Category: Ubiquitin]]
[[Category: Ubiquitin-binding protein]]
[[Category: Usp]]
[[Category: Znf-ubp]]
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