2i96: Difference between revisions
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==Solution structure of the oxidized microsomal human cytochrome b5== | ==Solution structure of the oxidized microsomal human cytochrome b5== | ||
<StructureSection load='2i96' size='340' side='right'caption='[[2i96 | <StructureSection load='2i96' size='340' side='right'caption='[[2i96]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2i96]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2i96]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2I96 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2I96 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i96 OCA], [https://pdbe.org/2i96 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i96 RCSB], [https://www.ebi.ac.uk/pdbsum/2i96 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i96 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2i96 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2i96 OCA], [https://pdbe.org/2i96 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2i96 RCSB], [https://www.ebi.ac.uk/pdbsum/2i96 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2i96 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
[https://www.uniprot.org/uniprot/CYB5_HUMAN CYB5_HUMAN] Defects in CYB5A are the cause of methemoglobinemia CYB5A-related (METHB-CYB5A) [MIM:[https://omim.org/entry/250790 250790]. A form of methemoglobinemia, a hematologic disease characterized by the presence of excessive amounts of methemoglobin in blood cells, resulting in decreased oxygen carrying capacity of the blood, cyanosis and hypoxia.<ref>PMID:8168836</ref> | |||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/CYB5_HUMAN CYB5_HUMAN] Cytochrome b5 is a membrane bound hemoprotein which function as an electron carrier for several membrane bound oxygenases. | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Nunez-Quintana M]] | |||
[[Category: Nunez-Quintana | [[Category: Truan G]] | ||
[[Category: Truan | [[Category: Van Heijenoort C]] | ||
[[Category: | |||
Revision as of 19:03, 29 May 2024
Solution structure of the oxidized microsomal human cytochrome b5
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