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==Solution Structure of Human Supervillin Headpiece, Minimized Average==
==Solution Structure of Human Supervillin Headpiece, Minimized Average==
<StructureSection load='2k6n' size='340' side='right'caption='[[2k6n]], [[NMR_Ensembles_of_Models | 1 NMR models]]' scene=''>
<StructureSection load='2k6n' size='340' side='right'caption='[[2k6n]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2k6n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K6N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K6N FirstGlance]. <br>
<table><tr><td colspan='2'>[[2k6n]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2K6N OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2K6N FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2k6m|2k6m]], [[1yu5|1yu5]], [[1qzp|1qzp]], [[1zv6|1zv6]], [[1qqv|1qqv]], [[1yu7|1yu7]], [[1unc|1unc]], [[1und|1und]], [[1yu8|1yu8]], [[1vii|1vii]], [[2ppz|2ppz]], [[1ujs|1ujs]], [[1yrf|1yrf]], [[1yri|1yri]], [[2jm0|2jm0]], [[1wy3|1wy3]], [[1wy4|1wy4]]</div></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SVIL ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k6n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k6n OCA], [https://pdbe.org/2k6n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k6n RCSB], [https://www.ebi.ac.uk/pdbsum/2k6n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k6n ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2k6n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2k6n OCA], [https://pdbe.org/2k6n PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2k6n RCSB], [https://www.ebi.ac.uk/pdbsum/2k6n PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2k6n ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/SVIL_HUMAN SVIL_HUMAN]] Forms a high-affinity link between the actin cytoskeleton and the membrane. Isoform 1 (archvillin) is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation. Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function. Isoform 2 may be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adehesions involves binding to TRIP6 (By similarity).<ref>PMID:19109420</ref>
[https://www.uniprot.org/uniprot/SVIL_HUMAN SVIL_HUMAN] Forms a high-affinity link between the actin cytoskeleton and the membrane. Isoform 1 (archvillin) is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation. Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function. Isoform 2 may be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adehesions involves binding to TRIP6 (By similarity).<ref>PMID:19109420</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Brown, J W]]
[[Category: Brown JW]]
[[Category: Didem, V]]
[[Category: Didem V]]
[[Category: McKnight, C]]
[[Category: McKnight C]]
[[Category: Actin capping]]
[[Category: Actin-binding]]
[[Category: Alternative splicing]]
[[Category: Archvillin]]
[[Category: Calcium]]
[[Category: Cytoplasm]]
[[Category: Cytoskeleton]]
[[Category: Headpiece]]
[[Category: Hp]]
[[Category: Membrane]]
[[Category: Phosphoprotein]]
[[Category: Polymorphism]]
[[Category: Structural protein]]
[[Category: Supervillin]]
[[Category: Svhp]]
[[Category: Villin]]
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