2osg: Difference between revisions
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==Solution Structure and Binding Property of the Domain-swapped Dimer of ZO2PDZ2== | ==Solution Structure and Binding Property of the Domain-swapped Dimer of ZO2PDZ2== | ||
<StructureSection load='2osg' size='340' side='right'caption='[[2osg | <StructureSection load='2osg' size='340' side='right'caption='[[2osg]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2osg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2osg]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OSG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2OSG FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2osg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2osg OCA], [https://pdbe.org/2osg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2osg RCSB], [https://www.ebi.ac.uk/pdbsum/2osg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2osg ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2osg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2osg OCA], [https://pdbe.org/2osg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2osg RCSB], [https://www.ebi.ac.uk/pdbsum/2osg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2osg ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Disease == | == Disease == | ||
[https://www.uniprot.org/uniprot/ZO2_HUMAN ZO2_HUMAN] Defects in TJP2 are involved in familial hypercholanemia (FHCA) [MIM:[https://omim.org/entry/607748 607748]. FHCA is a disorder characterized by elevated serum bile acid concentrations, itching, and fat malabsorption.<ref>PMID:12704386</ref> | |||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/ZO2_HUMAN ZO2_HUMAN] Plays a role in tight junctions and adherens junctions. | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Ji | [[Category: Ji P]] | ||
[[Category: Shi | [[Category: Shi YY]] | ||
[[Category: Wu | [[Category: Wu JH]] | ||
[[Category: Wu | [[Category: Wu JW]] | ||
[[Category: Yang | [[Category: Yang YS]] | ||
[[Category: Zhang | [[Category: Zhang JH]] | ||
