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==NMR Structure of The S. Aureus VraR DNA Binding Domain==
==NMR Structure of The S. Aureus VraR DNA Binding Domain==
<StructureSection load='2rnj' size='340' side='right'caption='[[2rnj]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
<StructureSection load='2rnj' size='340' side='right'caption='[[2rnj]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2rnj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/"micrococcus_aureus"_(rosenbach_1884)_zopf_1885 "micrococcus aureus" (rosenbach 1884) zopf 1885]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RNJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RNJ FirstGlance]. <br>
<table><tr><td colspan='2'>[[2rnj]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Staphylococcus_aureus Staphylococcus aureus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RNJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RNJ FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">vraR ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1280 "Micrococcus aureus" (Rosenbach 1884) Zopf 1885])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rnj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rnj OCA], [https://pdbe.org/2rnj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rnj RCSB], [https://www.ebi.ac.uk/pdbsum/2rnj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rnj ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rnj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rnj OCA], [https://pdbe.org/2rnj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rnj RCSB], [https://www.ebi.ac.uk/pdbsum/2rnj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rnj ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/VRAR_STAAM VRAR_STAAM]] Member of the two-component regulatory system VraS/VraR involved in the control of the cell wall peptidoglycan biosynthesis. VraR is overexpressed in strain Mu50, which leads to vancomycin resistance.  
[https://www.uniprot.org/uniprot/VRAR_STAAM VRAR_STAAM] Member of the two-component regulatory system VraS/VraR involved in the control of the cell wall peptidoglycan biosynthesis. VraR is overexpressed in strain Mu50, which leads to vancomycin resistance.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Donaldson, L W]]
[[Category: Staphylococcus aureus]]
[[Category: Activator]]
[[Category: Donaldson LW]]
[[Category: Antibiotic resistance]]
[[Category: Cytoplasm]]
[[Category: Dna binding domain]]
[[Category: Dna-binding]]
[[Category: Hth luxr-type domain]]
[[Category: Phosphoprotein]]
[[Category: Phosphorylation]]
[[Category: Transcription]]
[[Category: Transcription regulation]]
[[Category: Two-component regulatory system]]
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