Protein phosphatase

spinqualitylabelsall models Human PP2A catalytic (green) and regulatory (cyan) subunits complex with tumor-inducing toxin and sulfate 3k7v Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Protein phosphatases (PP) or serine/threonine protein phosphatase regulate protein phosphorylation and thus are key in intracellular signal transduction processes. PP1 is a serine/threonine phosphatase and is a key component of the insulin signaling pathway. PPM1K PP2A targets proteins in the oncogenic signaling pathways. For PP2A see also HEAT Repeat. PP2C are Mg/Mn-dependent and are essential for the regulation of cell cycle and stress signaling pathways. For details see Protein Phosphatase 2C ABA-regulated Protein Phosphatase 2C ABA Signaling Pathway. PP4 regulates a variety of cellular functions. PP5 is activated by lipids and is involved in signal transduction. Disease Mutations in PP2A are found in many solid cancers and leukemias. PP2A-activating drugs are possible candidates for cancer therapeutics protocols. Development of Alzheimer disease drugs could be based on restoration of PP2A activity. Structural highlights Human PP2A catalytic (green) and regulatory (cyan) subunits complex with tumor-inducing toxin. Algal toxin binds at the surface pocket of the PP2A catalytic subunit which contains the Mn+2 ion cofactors. Water molecule are shown as red sphere. Mn+2 ion cofactors coordination site. Whole binding site. 3D Structures of protein phosphatase Protein phosphatase 3D structures

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Michal Harel, Alexander Berchansky, Alexsandra Tifane Santos do Nascimento, Joel L. Sussman