9bvs: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 9bvs is ~~ON HOLD~~

==NMR structure of TLP-1 in solution==

~~Authors~~: ~~Jia~~, R., ~~McShan~~, A.C.

== Structural highlights ==

<table><tr><td colspan='2'>[[9bvs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rana_temporaria Rana temporaria]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9BVS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9BVS FirstGlance]. <br>

~~Description~~: ~~NMR structure~~ of ~~TLP~~-1 in ~~solution~~

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9bvs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9bvs OCA], [https://pdbe.org/9bvs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9bvs RCSB], [https://www.ebi.ac.uk/pdbsum/9bvs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9bvs ProSAT]</span></td></tr>

[[Category: Jia, R]]

</table>

[[Category: ~~Mcshan, A.C~~]]

== Function ==

[https://www.uniprot.org/uniprot/TPL_RANTE TPL_RANTE] Amphipathic alpha-helical antimicrobial peptide with potent activity against both Gram-negative and Gram-positive bacteria, and against fungi (PubMed:12133008, PubMed:16867990, PubMed:18370376, PubMed:31358802, PubMed:9022710). Mainly acts by causing perturbation of bilayer integrity of both neutral and negatively charged membranes, probably by forming pore-like openings (PubMed:12133008, PubMed:31358802). Also displays anti-leishmania activity by damaging parasite membrane (By similarity). Shows hemolytic activity (PubMed:12133008). Also shows cytotoxicity against cancer cell lines (PubMed:12133008). Strongly binds to lipopolysaccharides (LPS) and its lipid A portion (Probable) (PubMed:16801429). Improves temporin-A and temporin-B activities by preventing their homo-oligomerization in LPS (PubMed:16867990, PubMed:21586570). In vivo, its simultaneous administration with beta-lactam antibiotics produces the highest antimicrobial activities and the strongest reduction in plasma LPS and TNF-alpha levels, resulting in the highest survival rates in rat models of septic shock (PubMed:16801429).[UniProtKB:P56917][UniProtKB:P79874]<ref>PMID:12133008</ref> <ref>PMID:16801429</ref> <ref>PMID:16867990</ref> <ref>PMID:18370376</ref> <ref>PMID:21586570</ref> <ref>PMID:31358802</ref> <ref>PMID:9022710</ref> <ref>PMID:21586570</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Large Structures]]

[[Category: Rana temporaria]]

[[Category: Jia R]]

[[Category: McShan AC]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9bvs is ON HOLD
+==NMR structure of TLP-1 in solution==
+<StructureSection load='9bvs' size='340' side='right'caption='[[9bvs]]' scene=''>
-Authors: Jia, R., McShan, A.C.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9bvs]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rana_temporaria Rana temporaria]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9BVS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9BVS FirstGlance]. <br>
-Description: NMR structure of TLP-1 in solution
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9bvs FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9bvs OCA], [https://pdbe.org/9bvs PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9bvs RCSB], [https://www.ebi.ac.uk/pdbsum/9bvs PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9bvs ProSAT]</span></td></tr>
-[[Category: Jia, R]]
+</table>
-[[Category: Mcshan, A.C]]
+== Function ==
+[https://www.uniprot.org/uniprot/TPL_RANTE TPL_RANTE] Amphipathic alpha-helical antimicrobial peptide with potent activity against both Gram-negative and Gram-positive bacteria, and against fungi (PubMed:12133008, PubMed:16867990, PubMed:18370376, PubMed:31358802, PubMed:9022710). Mainly acts by causing perturbation of bilayer integrity of both neutral and negatively charged membranes, probably by forming pore-like openings (PubMed:12133008, PubMed:31358802). Also displays anti-leishmania activity by damaging parasite membrane (By similarity). Shows hemolytic activity (PubMed:12133008). Also shows cytotoxicity against cancer cell lines (PubMed:12133008). Strongly binds to lipopolysaccharides (LPS) and its lipid A portion (Probable) (PubMed:16801429). Improves temporin-A and temporin-B activities by preventing their homo-oligomerization in LPS (PubMed:16867990, PubMed:21586570). In vivo, its simultaneous administration with beta-lactam antibiotics produces the highest antimicrobial activities and the strongest reduction in plasma LPS and TNF-alpha levels, resulting in the highest survival rates in rat models of septic shock (PubMed:16801429).[UniProtKB:P56917][UniProtKB:P79874]<ref>PMID:12133008</ref> <ref>PMID:16801429</ref> <ref>PMID:16867990</ref> <ref>PMID:18370376</ref> <ref>PMID:21586570</ref> <ref>PMID:31358802</ref> <ref>PMID:9022710</ref> <ref>PMID:21586570</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Rana temporaria]]
+[[Category: Jia R]]
+[[Category: McShan AC]]