7e27: Difference between revisions

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<StructureSection load='7e27' size='340' side='right'caption='[[7e27]], [[Resolution|resolution]] 2.29&Aring;' scene=''>
<StructureSection load='7e27' size='340' side='right'caption='[[7e27]], [[Resolution|resolution]] 2.29&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[7e27]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Plasmodium_falciparum_3D7 Plasmodium falciparum 3D7]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7E27 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7E27 FirstGlance]. <br>
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7E27 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7E27 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HV6:(Z)-4,4,5,5,5-pentakis(fluoranyl)-1-(4-methoxy-2-oxidanyl-phenyl)-3-oxidanyl-pent-2-en-1-one'>HV6</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.29&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=HV6:(Z)-4,4,5,5,5-pentakis(fluoranyl)-1-(4-methoxy-2-oxidanyl-phenyl)-3-oxidanyl-pent-2-en-1-one'>HV6</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7e27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7e27 OCA], [https://pdbe.org/7e27 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7e27 RCSB], [https://www.ebi.ac.uk/pdbsum/7e27 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7e27 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7e27 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7e27 OCA], [https://pdbe.org/7e27 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7e27 RCSB], [https://www.ebi.ac.uk/pdbsum/7e27 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7e27 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/O77389_PLAF7 O77389_PLAF7]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Plasmodium falciparum, the deadliest causal agent of malaria, caused more than half of the 229 million malaria cases worldwide in 2019. The emergence and spreading of frontline drug-resistant Plasmodium strains are challenging to overcome in the battle against malaria and raise urgent demands for novel antimalarial agents. The P. falciparum formate-nitrite transporter (PfFNT) is a potential drug target due to its housekeeping role in lactate efflux during the intraerythrocytic stage. Targeting PfFNT, MMV007839 was identified as a lead compound that kills parasites at submicromolar concentrations. Here, we present 2 cryogenic-electron microscopy (cryo-EM) structures of PfFNT, one with the protein in its apo form and one with it in complex with MMV007839, both at 2.3 A resolution. Benefiting from the high-resolution structures, our study provides the molecular basis for both the lactate transport of PfFNT and the inhibition mechanism of MMV007839, which facilitates further antimalarial drug design.
Structural characterization of the Plasmodium falciparum lactate transporter PfFNT alone and in complex with antimalarial compound MMV007839 reveals its inhibition mechanism.,Peng X, Wang N, Zhu A, Xu H, Li J, Zhou Y, Wang C, Xiao Q, Guo L, Liu F, Jia ZJ, Duan H, Hu J, Yuan W, Geng J, Yan C, Jiang X, Deng D PLoS Biol. 2021 Sep 9;19(9):e3001386. doi: 10.1371/journal.pbio.3001386., eCollection 2021 Sep. PMID:34499638<ref>PMID:34499638</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 7e27" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Plasmodium falciparum 3D7]]
[[Category: Deng D]]
[[Category: Deng D]]
[[Category: Jiang X]]
[[Category: Jiang X]]
[[Category: Li J]]
[[Category: Peng X]]
[[Category: Wang N]]
[[Category: Xu H]]
[[Category: Yan CY]]
[[Category: Yan CY]]
[[Category: Zhu A]]

Latest revision as of 05:43, 5 June 2024

Structure of PfFNT in complex with MMV007839

7e27, resolution 2.29Å

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