7et2: Difference between revisions

From Proteopedia
Jump to navigationJump to search
← Older edit
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
OCA (talk | contribs)
Bots, Bureaucrats, journal, Administrators
3,328,572 edits
No edit summary
 
Line 3: Line 3:
<StructureSection load='7et2' size='340' side='right'caption='[[7et2]], [[Resolution|resolution]] 4.20&Aring;' scene=''>
<StructureSection load='7et2' size='340' side='right'caption='[[7et2]], [[Resolution|resolution]] 4.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[7et2]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Human_cytomegalovirus Human cytomegalovirus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ET2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ET2 FirstGlance]. <br>
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ET2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ET2 FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7et2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7et2 OCA], [https://pdbe.org/7et2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7et2 RCSB], [https://www.ebi.ac.uk/pdbsum/7et2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7et2 ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7et2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7et2 OCA], [https://pdbe.org/7et2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7et2 RCSB], [https://www.ebi.ac.uk/pdbsum/7et2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7et2 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[[https://www.uniprot.org/uniprot/Q6RXD3_HCMV Q6RXD3_HCMV]] Forms a portal in the viral capsid through which viral DNA is translocated during DNA packaging. Assembles as a dodecamer at a single fivefold axe of the T=16 icosahedric capsid. Binds to the molecular motor that translocates the viral DNA, termed terminase.[HAMAP-Rule:MF_04012]
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
How the human cytomegalovirus (HCMV) genome-the largest among human herpesviruses-is packaged, retained, and ejected remains unclear. We present the in situ structures of the symmetry-mismatched portal and the capsid vertex-specific components (CVSCs) of HCMV. The 5-fold symmetric 10-helix anchor-uncommon among known portals-contacts the portal-encircling DNA, which is presumed to squeeze the portal as the genome packaging proceeds. We surmise that the 10-helix anchor dampens this action to delay the portal reaching a "head-full" packaging state, thus facilitating the large genome to be packaged. The 6-fold symmetric turret, latched via a coiled coil to a helix from a major capsid protein, supports the portal to retain the packaged genome. CVSCs at the penton vertices-presumed to increase inner capsid pressure-display a low stoichiometry, which would aid genome retention. We also demonstrate that the portal and capsid undergo conformational changes to facilitate genome ejection after viral cell entry.


Structural basis for genome packaging, retention, and ejection in human cytomegalovirus.,Li Z, Pang J, Dong L, Yu X Nat Commun. 2021 Jul 27;12(1):4538. doi: 10.1038/s41467-021-24820-3. PMID:34315863<ref>PMID:34315863</ref>
==See Also==
 
*[[Portal protein 3D structures|Portal protein 3D structures]]
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 7et2" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human cytomegalovirus]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Li, Z]]
[[Category: Li Z]]
[[Category: Yu, X]]
[[Category: Yu X]]
[[Category: C12 portal]]
[[Category: Partially-enveloped capsid]]
[[Category: Viral protein]]
Retrieved from "https://proteopedia.org/7et2"