7n97: Difference between revisions
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==== | ==State 2 of TcdB and FZD2 at pH5== | ||
<StructureSection load='7n97' size='340' side='right'caption='[[7n97]]' scene=''> | <StructureSection load='7n97' size='340' side='right'caption='[[7n97]], [[Resolution|resolution]] 5.10Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br> | <table><tr><td colspan='2'>[[7n97]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Clostridioides_difficile Clostridioides difficile] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7N97 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7N97 FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7n97 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7n97 OCA], [https://pdbe.org/7n97 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7n97 RCSB], [https://www.ebi.ac.uk/pdbsum/7n97 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7n97 ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 5.1Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7n97 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7n97 OCA], [https://pdbe.org/7n97 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7n97 RCSB], [https://www.ebi.ac.uk/pdbsum/7n97 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7n97 ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/FZD2_HUMAN FZD2_HUMAN] Receptor for Wnt proteins. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. A second signaling pathway involving PKC and calcium fluxes has been seen for some family members, but it is not yet clear if it represents a distinct pathway or if it can be integrated in the canonical pathway, as PKC seems to be required for Wnt-mediated inactivation of GSK-3 kinase. Both pathways seem to involve interactions with G-proteins. May be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Clostridioides difficile]] | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Jiang M]] | ||
[[Category: Zhang J]] | |||
