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<StructureSection load='7sn7' size='340' side='right'caption='[[7sn7]], [[Resolution|resolution]] 4.20&Aring;' scene=''>
<StructureSection load='7sn7' size='340' side='right'caption='[[7sn7]], [[Resolution|resolution]] 4.20&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[7sn7]] is a 23 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli_o127:h6 Escherichia coli o127:h6]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SN7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SN7 FirstGlance]. <br>
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7SN7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7SN7 FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7sn7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7sn7 OCA], [https://pdbe.org/7sn7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7sn7 RCSB], [https://www.ebi.ac.uk/pdbsum/7sn7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7sn7 ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7sn7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7sn7 OCA], [https://pdbe.org/7sn7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7sn7 RCSB], [https://www.ebi.ac.uk/pdbsum/7sn7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7sn7 ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Flagellar filaments function as the propellers of the bacterial flagellum and their supercoiling is key to motility. The outer domains on the surface of the filament are non-critical for motility in many bacteria and their structures and functions are not conserved. Here, we show the atomic cryo-electron microscopy structures for flagellar filaments from enterohemorrhagic Escherichia coli O157:H7, enteropathogenic E. coli O127:H6, Achromobacter, and Sinorhizobium meliloti, where the outer domains dimerize or tetramerize to form either a sheath or a screw-like surface. These dimers are formed by 180 degrees rotations of half of the outer domains. The outer domain sheath (ODS) plays a role in bacterial motility by stabilizing an intermediate waveform and prolonging the tumbling of E. coli cells. Bacteria with these ODS and screw-like flagellar filaments are commonly found in soil and human intestinal environments of relatively high viscosity suggesting a role for the dimerization in these environments.


Flagellin outer domain dimerization modulates motility in pathogenic and soil bacteria from viscous environments.,Kreutzberger MAB, Sobe RC, Sauder AB, Chatterjee S, Pena A, Wang F, Giron JA, Kiessling V, Costa TRD, Conticello VP, Frankel G, Kendall MM, Scharf BE, Egelman EH Nat Commun. 2022 Mar 17;13(1):1422. doi: 10.1038/s41467-022-29069-y. PMID:35301306<ref>PMID:35301306</ref>
==See Also==
 
*[[Flagellin 3D structures|Flagellin 3D structures]]
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 7sn7" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Escherichia coli o127:h6]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Chatterjee, S]]
[[Category: Chatterjee S]]
[[Category: Egelman, E H]]
[[Category: Egelman EH]]
[[Category: Frankel, G]]
[[Category: Frankel G]]
[[Category: Kreutzberger, M A.B]]
[[Category: Kreutzberger MAB]]
[[Category: Bacteria flagellar filament]]
[[Category: Flagellar polymorphism]]
[[Category: Motility]]
[[Category: Structural protein]]

Latest revision as of 05:51, 5 June 2024

Cryo-EM structure of the enteropathogenic E. coli O127:H6 flagellar filament

7sn7, resolution 4.20Å

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