Contactin

spinqualitylabelsall models Mouse contactin-3 domains Ig1-Ig4 complex with glycerol (PDB code 5i99) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Contactin (CNTN) is a neuronal cell surface glycoprotein which associates with sodium channel and enhances the density of these channels on the plasma membrane in mammalian expression systems. Contactin-2 is a synaptic membrane protein involved in pathology of Alzheimer Disease. Contactin-4 , contactin-5 and contactin-6 are involved in brain developmen. Disease Mutations in contactin-4, contactin-5 and contactin-6 are confer risk of autism .

3D structures of contactin

Updated on 09-June-2024

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• Contactin-1
  • 3s97 – hCNTN Ig2-Ig3 domains + receptor-type tyrosine-protein phosphatase ζ - human
    
  • 2ee2 – hCNTN FN3 domains - NMR
    
  • 5e53 – cCNTN FN1-FN3 domains – chicken
    
• Contactin-2
  • 2om5 – hCNTN Ig1-Ig4 domains
    
  • 5e7l – mCNTN FN1-FN3 domains – mouse
    
• Contactin-3
  • 5e4q – mCNTN FN1-FN3 domains
    
  • 5i99 – mCNTN Ig5-FN2 domains
    
  • 5e5r – mCNTN Ig2-Ig3 domains + receptor-type tyrosine-protein phosphatase γ
    
  • 7mrm – cCNTN FN1-FN2 domains + APPb
    
• Contactin-4
  • 5e4s – mCNTN FN1-FN3 domains
    
  • 3jxa – mCNTN Ig1-Ig4 domains
    
  • 3kld – mCNTN Ig2-Ig3 domains + receptor-type tyrosine-protein phosphatase γ
    
  • 7mrq – cCNTN FN1-FN3 domains
    
  • 7mro – zCNTN FN1-FN3 domains 600-903 – zebrafish
    
  • 7mrk, 7mrs – zCNTN FN1-FN3 domains + APPb
    
  • 7mqy – zCNTN FN1-FN3 domains + APLP2
    
• Contactin-5
  • 5e52 – hCNTN FN1-FN3 domains
    
  • 4n68 – hCNTN FN3 domains
    
  • 5e4i – mCNTN Ig1-Ig4 domains 96-477
    
  • 7mrn – mCNTN FN1-FN3 domains 669-970 + APP
    
• Contactin-6
  • 5e55 – mCNTN FN1-FN3 domains
    
  • 5e5u – mCNTN Ig2-Ig3 domains + receptor-type tyrosine-protein phosphatase gamma
    

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel