End-binding protein

spinqualitylabelsall models Human end-binding protein 1 C terminal (grey) complex with dynactin-1 CAP-GLY domain (green) (PDB code 2hkq) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D End-binding protein or telomere-binding protein or microtubule-associated protein RP/EB family member (EB) regulates microtubules dynamics, promotes colony formation and enhances tumor growth. EB is part of the proteins which accumulate at the growing microtubule plus end. During mitosis the EB associates with centrosome and spindle microtubules. EB is involved in the regulation of chromosome stability and microtubule structure. The C terminal domains of EB1 and EB3 are involved in dimer formation. The CH (Calponin Homology) domain is an actin-binding domain. End-binding protein 1 accumulates at growing microtubule ends and regulates their dynamics. End-binding protein 2 is involved in initial microtubule reorganization promoting stability and bundle formation.

3D Structures of end-binding protein

Updated on 16-June-2024

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• End-binding protein 1 (MAPRE1)

• • 1pa7, 1ueg, 1vka, 2r8u – hEB1 N terminal – human
    
  • 1wu9 – hEB1 C terminal
    
  • 1yib, 1yig – hEB1 C terminal (mutant)
    
  • 1txq, 2hkq, 2hl5 – hEB1 C terminal + dynactin
    
  • 3gjo – hEB1 C terminal + dystonin
    
  • 2qjz – hEB1 CH domain 12-133
    
  • 5n74 – hEB1 + KAR9
    
  • 1v5k – mEB1 CH domain (mutant) – mouse - NMR
    
  • 6evi – mEB1 C-terminal 191-260 - NMR
    
  • 6evj – mEB1 C-terminal + modulator - NMR
    
  • 7olg – mEB1 C-terminal + peptide - NMR
    
  • 1k8g, 1kix, 1otc, 1ph1, 1ph2, 1ph3, 1ph4, 1ph5, 1ph6, 1ph7, 1ph8, 1ph9, 1phj – EB1 alpha+beta subunits + DNA – Sterkiella nova
    
• End-binding protein 3

• • 3co1 – hEB3 CH domain
    
  • 1wyo – hEB3 CH domain - NMR
    
  • 3jak, 7sj9 – hEB3 + tubulin – Cryo EM
    
  • 3jal – hEB3 + tubulin + GMPCPP – Cryo EM
    
• End-binding protein 1+3

• • 3tq7 – hEB3 C terminal + hEB1 C terminal + dynactin
    

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Michal Harel, Openfox