Exportin

spinqualitylabelsall models Structure of yeast exportin-5 (magenta) complex with GTPaseRan (cyan), Mg+2 (green) and RNA (PDB code 3icq). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Exportins (XPO) or chromosomal maintenance protein mediate the nuclear export of cellular proteins with a leucine-rich export signal (NES) and RNA. XPO is regulated by GTPaseRan. RanGTP bind to XPO forming a ternary complex with the exported protein. The complex diffuses through the nuclear core complex to the cytoplasm and then dissociates. XPO-1 mediates nuclear transport of cellular proteins bearing a Leu-rich nuclear export signal and of RNA. XPO-4 mediates nuclear transport of eukaryotic translation initiation factor 5A. XPO-5 mediates nuclear transport of pre-miroRNAs and short hairpin RNAs. XPO-t exports tRNA from the nucleus. Structural highlights Yeast exportin-5 with GTPaseRan, Mg+2 and RNA. GTP binding site. Mg coordination site (PDB code 3icq). 3D structures of exportin Exportin 3D structures

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Michal Harel, Alexander Berchansky