Gasdermin: Difference between revisions
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'''Gasdermin''' (GSDM) is the substrate of the inflammatory [[Caspase]] downstream from inflammasomes which activate caspase. Inflammasomes are supramolecular signalling assemblies activating the lytic process against exogenous pathogens. GSDM is required for cytokine release and pyroptosis, a lytic form of programmed cell death) <ref>PMID:31451512</ref>. Pyropptosis is the regulated lytic cell death mediated by GSMD pore formation. GSDM D contains 2 domains: the N-terminal fragment which is pore-forming and the repressive C-terminal. The GSDM family contains 6 members in human. | '''Gasdermin''' (GSDM) is the substrate of the inflammatory [[Caspase]] downstream from inflammasomes which activate caspase. Inflammasomes are supramolecular signalling assemblies activating the lytic process against exogenous pathogens. GSDM is required for cytokine release and pyroptosis, a lytic form of programmed cell death) <ref>PMID:31451512</ref>. Pyropptosis is the regulated lytic cell death mediated by GSMD pore formation. GSDM D contains 2 domains: the N-terminal fragment which is pore-forming and the repressive C-terminal. The GSDM family contains 6 members in human. | ||
*'''Gasdermin B''' has a role in antibacterial defense, inflammatory pathologies and cancer<ref>PMID:37997534</ref>. | |||
*'''Gasdermin D''' is a pore-forming protein involved in cell death of macrophages<ref>PMID:32800355</ref>. | *'''Gasdermin D''' is a pore-forming protein involved in cell death of macrophages<ref>PMID:32800355</ref>. | ||
