Geranylgeranyl transferase

spinqualitylabelsall models Structure of rat geranylgeranyl transferase type 2 subunitsα (magenta) and β (cyan) complex with geranylgeranyl pyrophosphate, Zn+2 (grey) and Ca+2 (green) ions (PDB code 3dst). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Geranylgeranyl transferase type 1 (GGT1) adds a 20-carbon isoprenoid group called geranylgeranyl (GG) to the C-terminal of proteins containing the CAAX motif (Cysteine, Aliphatic, Aliphatic, any amino acid). Geranylgeranyl transferase type 2 (GGT2) adds 2 GG groups to C-terminal cysteine residue of a protein. The addition of the hydrophobic prenyl group causes the proteins to become membrane-associated. Relevance GGT2 inhibitors block bone resorption and induces myeloma cell apoptosis. Structural highlights The active site with bound geranylgeranyl pyrophosphate contains a Zn+2 atom. Water molecules shown as red spheres. 3D structures of geranylgeranyl transferase Geranylgeranyl transferase 3D structures

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