8jxn: Difference between revisions
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==Human 3-methylcrotonyl-CoA carboxylase in BCCP-H1 state with MCoA== | |||
<StructureSection load='8jxn' size='340' side='right'caption='[[8jxn]], [[Resolution|resolution]] 3.20Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8jxn]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8JXN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8JXN FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.2Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BTI:5-(HEXAHYDRO-2-OXO-1H-THIENO[3,4-D]IMIDAZOL-6-YL)PENTANAL'>BTI</scene>, <scene name='pdbligand=TW3:~{S}-[2-[3-[[(2~{R})-4-[[[(2~{S},3~{S},4~{S},5~{S})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxy-3,3-dimethyl-2-oxidanyl-butanoyl]amino]propanoylamino]ethyl]+3-methylbut-2-enethioate'>TW3</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8jxn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8jxn OCA], [https://pdbe.org/8jxn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8jxn RCSB], [https://www.ebi.ac.uk/pdbsum/8jxn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8jxn ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: Tian | == Disease == | ||
[https://www.uniprot.org/uniprot/MCCB_HUMAN MCCB_HUMAN] 3-methylcrotonyl-CoA carboxylase deficiency. The disease is caused by variants affecting the gene represented in this entry. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/MCCB_HUMAN MCCB_HUMAN] Carboxyltransferase subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism.<ref>PMID:17360195</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Liu DS]] | |||
[[Category: Su JY]] | |||
[[Category: Tian XY]] | |||
Latest revision as of 07:15, 3 July 2024
Human 3-methylcrotonyl-CoA carboxylase in BCCP-H1 state with MCoA
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