Netrin

spinqualitylabelsall models Glycosylated mouse netrin-1 complex with Ca+2 and Cl-1 ions (PDB code 4ove) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Netrins (Net) direct cell and axon migration during development. Netrins are chemotropic. The growing axon moves either toward or away from netrin concentration. Netrins influence the formation of a variety of tissues. They act as chemoattractants for some cell types and chemorepellent for other types. Netrin-1 is a secreted protein while netrin-G2 is GPI-anchored membrane protein. Netrin-4 promotes neurite elongation at low concentration and inhibits neurite elongation at high concentration. Netrin-G1 promotes the growth of dorsal thalamic axons. Relevance Netrin-1 is over-expressed in glioblastoma tumor. Netrin-1 is a therapeutic target in cardiovascular diseases. Structural highlights The N-terminal of netrin-1 is homologous to the N-terminal type I domain of laminin (LN) followed by 3 cysteine-rich epidermal growth factor repeats. Ca coordination site. Water molecules are shown as red spheres. Cl coordination site.

3D Structures of netrin

Updated on 16-July-2024

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• Netrin-1
  • 7ne1 – hNet1 V-VI domains 39-453 + neogenin - human
    
  • 7ne0 – hNet1 V-VI domains + neogenin + RGMB
    
  • 7ndg – hNet1 V-VI domains + neogenin + RGMB – Cryo EM
    
  • 4urt – hNet1 V-VI domains + hNet receptor DCC fourth fibronectin type FN5-FN6 domains
    
  • 6fkq – hNet1 V-VI domains + draxin peptide
    
  • 4ove – mNet1 – mouse
    
  • 4plm, 7ler – cNet1 LN-LE3 domains 26-457 – chicken
    
  • 4pln – cNet1 LN-LE3 domains + neogenin fibronectin type IV-V domains
    
  • 4plo – cNet1 LN-LE3 domains + mNet receptor DCC fourth fibronectin type IV-V domains
    
  • 7lrf – cNet1 LN-LE3 domains + SOS
    
• Netrin-4
  • 4wnx – mNet4
    
• Netrin-G1
  • 3zyj – hNetG1 LAM + EGF1 domains (mutant) + leucine-rich repeat-containing protein
    
• Netrin-G2
  • 3tbd – hNetG2 VI + LE1 domains
    
  • 3zyg – hNetG2 LAM + EGF1 domains
    
  • 3zyi – hNetG2 LAM + EGF1 domains + leucine-rich repeat-containing protein
    

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Michal Harel, Alexander Berchansky