8tg9: Difference between revisions
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==Complex of NPR1 ectodomain with ANP plus an allosteric activating antibody, REGN5381== | |||
<StructureSection load='8tg9' size='340' side='right'caption='[[8tg9]], [[Resolution|resolution]] 3.08Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8tg9]] is a 7 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8TG9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8TG9 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.08Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8tg9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8tg9 OCA], [https://pdbe.org/8tg9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8tg9 RCSB], [https://www.ebi.ac.uk/pdbsum/8tg9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8tg9 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/ANPRA_HUMAN ANPRA_HUMAN] Receptor for the atrial natriuretic peptide NPPA/ANP and the brain natriuretic peptide NPPB/BNP which are potent vasoactive hormones playing a key role in cardiovascular homeostasis. Has guanylate cyclase activity upon binding of the ligand.<ref>PMID:1672777</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | |||
[[Category: Franklin MC]] | |||
[[Category: Romero Hernandez A]] | |||
Latest revision as of 12:22, 17 July 2024
Complex of NPR1 ectodomain with ANP plus an allosteric activating antibody, REGN5381
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