Pilin: Difference between revisions

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==Introduction==

'''Pilin''' (PIL) or '''fimbrial protein''' is a fibrous protein found in the pilus of bacteria. Pili in bacteria are used for exchange of DNA during bacterial conjugation. Type IV pili play an important role in the pathogenesis of many bacterial species; they are a required component for the adhesion of bacteria to their target cells. For example, Type IV pili are required for infection by the pathogens that cause cholera, typhoid, pneumonia, gonorrhea, and meningitis. <ref name=journal1>PMID:19626704</ref> They may also mediate transformation, modulate target-cell specificity and play a role in twitching motility. PilS is a protein that is a member of the pilin protein superfamily. <ref name=journal2>Asha M. Balakrishna,Yvonne Yih-Wan Tan, Henry Yu-Keung Mok,Anand M. Saxena,and Kunchithapadam Swaminathan. Crystallization and preliminary X-ray diffraction analysis of Salmonella typhi PilS. 2006 October 1; 62(Pt 10): 1024–1026</ref>

'''Pilin''' (PIL) or '''fimbrial protein''' is a fibrous protein found in the pilus of bacteria. Pili in bacteria are used for exchange of DNA during bacterial conjugation. '''Type IV pili''' play an important role in the pathogenesis of many bacterial species; they are a required component for the adhesion of bacteria to their target cells. For example, Type IV pili are required for infection by the pathogens that cause cholera, typhoid, pneumonia, gonorrhea, and meningitis. <ref name=journal1>PMID:19626704</ref> They may also mediate transformation, modulate target-cell specificity and play a role in twitching motility. PilS is a protein that is a member of the pilin protein superfamily. <ref name=journal2>Asha M. Balakrishna,Yvonne Yih-Wan Tan, Henry Yu-Keung Mok,Anand M. Saxena,and Kunchithapadam Swaminathan. Crystallization and preliminary X-ray diffraction analysis of Salmonella typhi PilS. 2006 October 1; 62(Pt 10): 1024–1026</ref>

==Structure==

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 ==Introduction==
-'''Pilin''' (PIL) or '''fimbrial protein''' is  a fibrous protein found in the pilus of bacteria.  Pili in bacteria are used for exchange of DNA during bacterial conjugation.  Type IV pili play an important role in the pathogenesis of many bacterial species; they are a required component for the adhesion of bacteria to their target cells. For example, Type IV pili are required for infection by the pathogens that cause cholera, typhoid, pneumonia, gonorrhea, and meningitis. <ref name=journal1>PMID:19626704</ref> They may also mediate transformation, modulate target-cell specificity and play a role in twitching motility. PilS is a protein that is a member of the pilin protein superfamily. <ref name=journal2>Asha M. Balakrishna,Yvonne Yih-Wan Tan, Henry Yu-Keung Mok,Anand M. Saxena,and Kunchithapadam Swaminathan. Crystallization and preliminary X-ray diffraction analysis of Salmonella typhi PilS. 2006 October 1; 62(Pt 10): 1024–1026</ref>
+'''Pilin''' (PIL) or '''fimbrial protein''' is  a fibrous protein found in the pilus of bacteria.  Pili in bacteria are used for exchange of DNA during bacterial conjugation.  '''Type IV pili''' play an important role in the pathogenesis of many bacterial species; they are a required component for the adhesion of bacteria to their target cells. For example, Type IV pili are required for infection by the pathogens that cause cholera, typhoid, pneumonia, gonorrhea, and meningitis. <ref name=journal1>PMID:19626704</ref> They may also mediate transformation, modulate target-cell specificity and play a role in twitching motility. PilS is a protein that is a member of the pilin protein superfamily. <ref name=journal2>Asha M. Balakrishna,Yvonne Yih-Wan Tan, Henry Yu-Keung Mok,Anand M. Saxena,and Kunchithapadam Swaminathan. Crystallization and preliminary X-ray diffraction analysis of Salmonella typhi PilS. 2006 October 1; 62(Pt 10): 1024–1026</ref>
 ==Structure==