ConSurfDB vs. ConSurf: Difference between revisions
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ConSurfDB has a result (NOT SHOWN) with an '''APD of 1.63'''. Conservation of important residues in the groove is obscured by inclusion in the MSA of proteins with different functions ([[#Example With Multiple Functions|see analysis above]]). The sides of the groove are variable, as expected (enabling it to bind a wide range of peptide sequences). The only groove residue that is conserved at greater than level 6 is '''Leu5''' (level 8), part of a hydrophobic pocket that binds a peptide "anchor residue". Only a handful of surface residues are highly conserved (level 9), including '''Trp274''' involved in binding CD8. | ConSurfDB has a result (NOT SHOWN) with an '''APD of 1.63'''. Conservation of important residues in the groove is obscured by inclusion in the MSA of proteins with different functions ([[#Example With Multiple Functions|see analysis above]]). The sides of the groove are variable, as expected (enabling it to bind a wide range of peptide sequences). The only groove residue that is conserved at greater than level 6 is '''Leu5''' (level 8), part of a hydrophobic pocket that binds a peptide "anchor residue". Only a handful of surface residues are highly conserved (level 9), including '''Trp274''' involved in binding CD8. | ||
<font color="red">UPDATE IN PROGRESS:</FONT> [[User:Eric Martz|Eric Martz]] 21:24, 23 July 2024 (UTC) | |||
Examples of conserved patches on other proteins, revealed by ConSurf, will be found in the articles on | Examples of conserved patches on other proteins, revealed by ConSurf, will be found in the articles on | ||
