ConSurfDB vs. ConSurf: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Eric Martz (talk | contribs) No edit summary |
Eric Martz (talk | contribs) No edit summary |
||
| Line 2: | Line 2: | ||
[[Image:2vaa-APD0.31-40degslow.gif]] | [[Image:2vaa-APD0.31-40degslow.gif]] | ||
</td></tr><tr><td> | </td></tr><tr><td> | ||
Conservation of amino acids non-covalently interacting with a peptide in the groove of [https://www.youtube.com/watch?v=2ZakngfbHSo Major Histocompatibility Protein] Class I ([[2vaa]]). Conservation was not revealed until an [[#Average Pairwise Distance]] of 0.31 was achieved in a customized ConSurf Server job. | {{Template:ColorKey_ConSurf_NoYellow_NoGray}} | ||
Conservation of amino acids non-covalently interacting with a peptide in the groove of [https://www.youtube.com/watch?v=2ZakngfbHSo Major Histocompatibility Protein] Class I ([[2vaa]]). Conservation was '''not revealed''' until an [[#Average Pairwise Distance]] of 0.31 was achieved in a customized ConSurf Server job. [[#Examples|DETAILS BELOW]]. | |||
</td></tr></table> | </td></tr></table> | ||
Evolutionary Conservation is introduced at [[Introduction to Evolutionary Conservation]], and treated in somewhat greater depth in the article [[Conservation, Evolutionary]]. These describe how conservation patterns in 3D can help to identify functional sites in proteins. Proteopedia displays conservation patterns pre-calculated by [http://consurfdb.tau.ac.il ConSurfDB], when available. These are usually based on broad protein families that include sequences of proteins with multiple functions. Consequently, they usually '''obscure conservation''' present in a family of proteins with a single function (see [[Conservation%2C_Evolutionary#Caveats|Caveats]]). | Evolutionary Conservation is introduced at [[Introduction to Evolutionary Conservation]], and treated in somewhat greater depth in the article [[Conservation, Evolutionary]]. These describe how conservation patterns in 3D can help to identify functional sites in proteins. Proteopedia displays conservation patterns pre-calculated by [http://consurfdb.tau.ac.il ConSurfDB], when available. These are usually based on broad protein families that include sequences of proteins with multiple functions. Consequently, they usually '''obscure conservation''' present in a family of proteins with a single function (see [[Conservation%2C_Evolutionary#Caveats|Caveats]]). | ||
