Conservation, Evolutionary: Difference between revisions
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===HotPatch=== | ===HotPatch=== | ||
[http://hotpatch.mbi.ucla.edu/ HotPatch] <ref>PMID: 17451744</ref> "finds unusual patches on the surface of proteins, and computes just how unusual they are (patch rareness), and how likely each patch is to be of functional importance (functional confidence (FC).) The statistical analysis is done by comparing your protein's surface against the surfaces of a large set of proteins whose functional sites are known." One advantage of HotPatch is that sequence homologs are not required. See the [http://consurfdb.tau.ac.il/comparison.php comparison of HotPatch with ConSurf for cytochrome c]. | In 2024, the HotPatch Server, formerly at UCLA, appears to be unavailable. <!-- | ||
[http://hotpatch.mbi.ucla.edu/ HotPatch] <ref>PMID: 17451744</ref> "finds unusual patches on the surface of proteins, and computes just how unusual they are (patch rareness), and how likely each patch is to be of functional importance (functional confidence (FC).) The statistical analysis is done by comparing your protein's surface against the surfaces of a large set of proteins whose functional sites are known." One advantage of HotPatch is that sequence homologs are not required. See the [http://consurfdb.tau.ac.il/comparison.php comparison of HotPatch with ConSurf for cytochrome c]. --> | |||
===Evolutionary Trace Viewer=== | ===Evolutionary Trace Viewer=== | ||
