Interpreting ConSurf Results: Difference between revisions
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The APD for the 2VAA result in the Gallery is '''0.99'''. The MSA has 150 sequences, largely limited to sequences for major histocompatibility complex class I proteins. The labels of 101 sequences (67% of 150) contain "class I" or "class 1". There is only one class II protein sequence. Three sequences are labeled "zinc-alpha-2-glycoprotein", clearly a different function. There are 22 sequences labeled "uncharacterized protein" which nevertheless have high similarity to the query. 19 sequences are labeled "UPI000... related cluster". If the uncharacterized and "UPI000..." sequences are in fact class I sequences, then '''up to 142/150 (95%) of the sequences could be MHC-I'''. | The APD for the 2VAA result in the Gallery is '''0.99'''. The MSA has 150 sequences, largely limited to sequences for major histocompatibility complex class I proteins. The labels of 101 sequences (67% of 150) contain "class I" or "class 1". There is only one class II protein sequence. Three sequences are labeled "zinc-alpha-2-glycoprotein", clearly a different function. There are 22 sequences labeled "uncharacterized protein" which nevertheless have high similarity to the query. 19 sequences are labeled "UPI000... related cluster". If the uncharacterized and "UPI000..." sequences are in fact class I sequences, then '''up to 142/150 (95%) of the sequences could be MHC-I'''. | ||
However, conservation of key functional residues was revealed only when custom ConSurf Server jobs achieved APD around 0.30: See [[ConSurfDB_vs._ConSurf#Examples | However, conservation of key functional residues was revealed only when custom ConSurf Server jobs achieved APD around 0.30: See Case #1 at[[ConSurfDB_vs._ConSurf#Examples]]. | ||
====APD 1.62==== | ====APD 1.62==== | ||
