8yw5: Difference between revisions
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==Cryo-EM structure of the retatrutide-bound human GCGR-Gs complex== | |||
<StructureSection load='8yw5' size='340' side='right'caption='[[8yw5]], [[Resolution|resolution]] 2.84Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8yw5]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8YW5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8YW5 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.84Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=2ML:2-METHYLLEUCINE'>2ML</scene>, <scene name='pdbligand=AIB:ALPHA-AMINOISOBUTYRIC+ACID'>AIB</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8yw5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8yw5 OCA], [https://pdbe.org/8yw5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8yw5 RCSB], [https://www.ebi.ac.uk/pdbsum/8yw5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8yw5 ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/GLR_HUMAN GLR_HUMAN] This is a receptor for glucagon which plays a central role in regulating the level of blood glucose by controlling the rate of hepatic glucose production and insulin secretion. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase and also a phosphatidylinositol-calcium second messenger system. | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: Yuan | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Synthetic construct]] | ||
[[Category: | [[Category: Cong ZT]] | ||
[[Category: Li WX]] | |||
[[Category: Li WZ]] | |||
[[Category: Wang MW]] | |||
[[Category: Xu HE]] | |||
[[Category: Yang DH]] | |||
[[Category: Yuan QN]] | |||
[[Category: Zhao FH]] | |||
[[Category: Zhao LH]] | |||
[[Category: Zhou QT]] | |||
Latest revision as of 05:44, 7 August 2024
Cryo-EM structure of the retatrutide-bound human GCGR-Gs complex
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