Spectrin: Difference between revisions
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[[Spectrin]] forms scaffolding in plasma membranes and cytoskeletal structure. It interacts with actin at either end of its tetramer<ref>PMID:17060500</ref>. The SPT dimer is formed by association of α1 and β1 monomers. In invertebrates there are SPT α, β and βH. In vertebrates there are SPT α1 (SPTA1), α2 (SPTA2) and β1 (SPTB1) to β5. SPT contains an SRC Homology 3 domain (SH3), a Pleckstrin Homology (PH) domain and a Calponin Homology (CH) domain. | [[Spectrin]] forms scaffolding in plasma membranes and cytoskeletal structure. It interacts with actin at either end of its tetramer<ref>PMID:17060500</ref>. The SPT dimer is formed by association of α1 and β1 monomers. In invertebrates there are SPT α, β and βH. In vertebrates there are SPT α1 (SPTA1), α2 (SPTA2) and β1 (SPTB1) to β5. SPT contains an SRC Homology 3 domain (SH3), a Pleckstrin Homology (PH) domain and a Calponin Homology (CH) domain. | ||
*'''Spectrin α2''' is expressed highly in heart muscle cells<ref>PMID:15360127</ref>. | *'''Spectrin α2''' is expressed highly in heart muscle cells<ref>PMID:15360127</ref>. | ||
*'''Spectrin β2''' is associated with GABA receptor at dendritic synapses<ref>PMID:36604600</ref>. | |||
*'''Spectrin β4''' is associated with GABA receptor at axon initial segment synapses. | |||
== Disease == | == Disease == | ||
