8kco: Difference between revisions
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The entry | ==Cryo-EM structure of human gamma-secretase in complex with RO4929097== | ||
<StructureSection load='8kco' size='340' side='right'caption='[[8kco]], [[Resolution|resolution]] 2.80Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8kco]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8KCO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8KCO FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.8Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8kco FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8kco OCA], [https://pdbe.org/8kco PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8kco RCSB], [https://www.ebi.ac.uk/pdbsum/8kco PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8kco ProSAT]</span></td></tr> | ||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/NICA_HUMAN NICA_HUMAN] Hidradenitis suppurativa. The disease is caused by mutations affecting the gene represented in this entry. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/NICA_HUMAN NICA_HUMAN] Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Guo X]] | |||
[[Category: Kai U]] | |||
[[Category: Lei J]] | |||
[[Category: Li H]] | |||
[[Category: Shi Y]] | |||
[[Category: Yan C]] | |||
[[Category: Zhou R]] | |||
Latest revision as of 08:15, 14 August 2024
Cryo-EM structure of human gamma-secretase in complex with RO4929097
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