8kct: Difference between revisions
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==Cryo-EM structure of human gamma-secretase in complex with Nirogacestat== | |||
<StructureSection load='8kct' size='340' side='right'caption='[[8kct]], [[Resolution|resolution]] 2.60Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8kct]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8KCT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8KCT FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.6Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8kct FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8kct OCA], [https://pdbe.org/8kct PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8kct RCSB], [https://www.ebi.ac.uk/pdbsum/8kct PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8kct ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: | == Disease == | ||
[[Category: | [https://www.uniprot.org/uniprot/NICA_HUMAN NICA_HUMAN] Hidradenitis suppurativa. The disease is caused by mutations affecting the gene represented in this entry. | ||
[[Category: | == Function == | ||
[[Category: Li | [https://www.uniprot.org/uniprot/NICA_HUMAN NICA_HUMAN] Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor required for the assembly of the gamma-secretase complex. | ||
[[Category: | __TOC__ | ||
[[Category: Yan | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Guo X]] | |||
[[Category: Kai U]] | |||
[[Category: Lei J]] | |||
[[Category: Li H]] | |||
[[Category: Shi Y]] | |||
[[Category: Yan C]] | |||
[[Category: Zhou R]] | |||
Latest revision as of 08:15, 14 August 2024
Cryo-EM structure of human gamma-secretase in complex with Nirogacestat
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