8pj6: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 8pj6 is ~~ON HOLD until Paper Publication~~

==Structure of human 48S translation initiation complex with initiator tRNA, eIF1A and eIF3 (off-pathway)==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[8pj6]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8PJ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8PJ6 FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.9Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8pj6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8pj6 OCA], [https://pdbe.org/8pj6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8pj6 RCSB], [https://www.ebi.ac.uk/pdbsum/8pj6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8pj6 ProSAT]</span></td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/EIF3B_HUMAN EIF3B_HUMAN] Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.<ref>PMID:9388245</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Fischer N]]

[[Category: Liedtke D]]

[[Category: Peng BZ]]

[[Category: Petrychenko V]]

[[Category: Rodnina MV]]

[[Category: Yi S-H]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 8pj6 is ON HOLD  until Paper Publication
+==Structure of human 48S translation initiation complex with initiator tRNA, eIF1A and eIF3 (off-pathway)==
+<StructureSection load='8pj6' size='340' side='right'caption='[[8pj6]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8pj6]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8PJ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8PJ6 FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.9&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8pj6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8pj6 OCA], [https://pdbe.org/8pj6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8pj6 RCSB], [https://www.ebi.ac.uk/pdbsum/8pj6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8pj6 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/EIF3B_HUMAN EIF3B_HUMAN] Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation.<ref>PMID:9388245</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Fischer N]]
+[[Category: Liedtke D]]
+[[Category: Peng BZ]]
+[[Category: Petrychenko V]]
+[[Category: Rodnina MV]]
+[[Category: Yi S-H]]