TNF receptor-associated factor

spinqualitylabelsall models Human TRAF2 TRAF domain (green) complex with TNFR type 1 associated death domain protein TRADD (deepskyblue) (PDB code 1f3v) Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function TNF receptor-associated factor (TRAF) are signal transducers and are involved in regulation of apoptosis, inflammation and antiviral response. There are 7 known TRAF proteins. All TRAF proteins share a C-terminal homology region named TRAF domain which can bind the cytoplasmic domain of receptors and other TRAF proteins. TRAF1 is the only TRAF which does not have N-terminal RING and zinc finger motifs. TRAF2, TRAF5 and TRAF6 mediate activation of NF-κB and JNK. TRAF3 mediates some innate immune receptor signals and regulates some post-translational modifications. TRAF4 is a binding partner of glycoproteins in platelets. Structural highlights The interaction of TRAF2 with the adaptor protein TRADD is bipartite with one part containing mainly hydrophobic interactions while the second part contains mainly polar interactions. Hydrophobic, Polar 3D Structures of TNF receptor-associated factor TNF receptor-associated factor 3D structures

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Michal Harel, Alexander Berchansky, Joel L. Sussman