8t7d: Difference between revisions

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'''Unreleased structure'''


The entry 8t7d is ON HOLD  until Paper Publication
==Crystal structure of wild type IDH1 bound to compound 1==
 
<StructureSection load='8t7d' size='340' side='right'caption='[[8t7d]], [[Resolution|resolution]] 3.44&Aring;' scene=''>
Authors: Lu, J., Abeywickrema, P., Heo, M.R., Parthasarathy, G., McCoy, M., Soisson, S.M.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8t7d]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8T7D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8T7D FirstGlance]. <br>
Description: Crystal structure of wild type IDH1 bound to compound 1
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.444&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8t7d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8t7d OCA], [https://pdbe.org/8t7d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8t7d RCSB], [https://www.ebi.ac.uk/pdbsum/8t7d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8t7d ProSAT]</span></td></tr>
[[Category: Abeywickrema, P]]
</table>
[[Category: Heo, M.R]]
== Disease ==
[[Category: Soisson, S.M]]
[https://www.uniprot.org/uniprot/IDHC_HUMAN IDHC_HUMAN] Defects in IDH1 are involved in the development of glioma (GLM) [MIM:[https://omim.org/entry/137800 137800]. Gliomas are central nervous system neoplasms derived from glial cells and comprise astrocytomas, glioblastoma multiforme, oligodendrogliomas, and ependymomas. Note=Mutations affecting Arg-132 are tissue-specific, and suggest that this residue plays a unique role in the development of high-grade gliomas. Mutations of Arg-132 to Cys, His, Leu or Ser abolish magnesium binding and abolish the conversion of isocitrate to alpha-ketoglutarate. Instead, alpha-ketoglutarate is converted to R(-)-2-hydroxyglutarate. Elevated levels of R(-)-2-hydroxyglutarate are correlated with an elevated risk of malignant brain tumors.
[[Category: Parthasarathy, G]]
== Function ==
[[Category: Mccoy, M]]
[https://www.uniprot.org/uniprot/IDHC_HUMAN IDHC_HUMAN]
[[Category: Lu, J]]
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Abeywickrema P]]
[[Category: Heo MR]]
[[Category: Lu J]]
[[Category: McCoy M]]
[[Category: Parthasarathy G]]
[[Category: Soisson SM]]
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