8uc5: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 8uc5 is ~~ON HOLD~~

==Apo X-ray crystal structure of Cyclophilin D with a surface entropy reduction mutation (K175I)==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[8uc5]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8UC5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8UC5 FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.43Å</td></tr>

[[Category: ~~Unreleased~~ Structures]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8uc5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8uc5 OCA], [https://pdbe.org/8uc5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8uc5 RCSB], [https://www.ebi.ac.uk/pdbsum/8uc5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8uc5 ProSAT]</span></td></tr>

</table>

== Function ==

[https://www.uniprot.org/uniprot/PPIF_HUMAN PPIF_HUMAN] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probablity of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial TP53 is involved in activating oxidative stress-induced necrosis. Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels. Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis.<ref>PMID:19228691</ref> <ref>PMID:22726440</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Kreitler DF]]

[[Category: Rangwala AM]]

[[Category: Seeliger MA]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 8uc5 is ON HOLD
+==Apo X-ray crystal structure of Cyclophilin D with a surface entropy reduction mutation (K175I)==
+<StructureSection load='8uc5' size='340' side='right'caption='[[8uc5]], [[Resolution|resolution]] 1.43&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8uc5]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8UC5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8UC5 FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.43&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8uc5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8uc5 OCA], [https://pdbe.org/8uc5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8uc5 RCSB], [https://www.ebi.ac.uk/pdbsum/8uc5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8uc5 ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/PPIF_HUMAN PPIF_HUMAN] PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probablity of the mPTP leading to apoptosis or necrosis; the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial TP53 is involved in activating oxidative stress-induced necrosis. Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels. Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis.<ref>PMID:19228691</ref> <ref>PMID:22726440</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Kreitler DF]]
+[[Category: Rangwala AM]]
+[[Category: Seeliger MA]]