8w2j: Difference between revisions
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==Human liver phosphofructokinase-1 filament in the T-state conformation== | |||
<StructureSection load='8w2j' size='340' side='right'caption='[[8w2j]], [[Resolution|resolution]] 3.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8w2j]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8W2J OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8W2J FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.1Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8w2j FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8w2j OCA], [https://pdbe.org/8w2j PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8w2j RCSB], [https://www.ebi.ac.uk/pdbsum/8w2j PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8w2j ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/PFKAL_HUMAN PFKAL_HUMAN] Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis (PubMed:22923583). Negatively regulates the phagocyte oxidative burst in response to bacterial infection by controlling cellular NADPH biosynthesis and NADPH oxidase-derived reactive oxygen species. Upon macrophage activation, drives the metabolic switch toward glycolysis, thus preventing glucose turnover that produces NADPH via pentose phosphate pathway (By similarity).[UniProtKB:P12382][HAMAP-Rule:MF_03184]<ref>PMID:22923583</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Kollman JM]] | |||
[[Category: Lynch EM]] | |||
[[Category: Webb BA]] | |||
Latest revision as of 06:08, 11 September 2024
Human liver phosphofructokinase-1 filament in the T-state conformation
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