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==The crystal structure of cyclohexadienyl dehydratase precursor from Pseudomonas aeruginosa PA01==
==The crystal structure of cyclohexadienyl dehydratase precursor from Pseudomonas aeruginosa PA01==
<StructureSection load='3kbr' size='340' side='right' caption='[[3kbr]], [[Resolution|resolution]] 1.66&Aring;' scene=''>
<StructureSection load='3kbr' size='340' side='right'caption='[[3kbr]], [[Resolution|resolution]] 1.66&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3kbr]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_aeruginosus"_(schroeter_1872)_trevisan_1885 "bacillus aeruginosus" (schroeter 1872) trevisan 1885]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KBR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3KBR FirstGlance]. <br>
<table><tr><td colspan='2'>[[3kbr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3KBR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3KBR FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.659&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EPE:4-(2-HYDROXYETHYL)-1-PIPERAZINE+ETHANESULFONIC+ACID'>EPE</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PA3475, pheC, Pseudomonas aeruginosa ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=287 "Bacillus aeruginosus" (Schroeter 1872) Trevisan 1885])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3kbr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kbr OCA], [https://pdbe.org/3kbr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3kbr RCSB], [https://www.ebi.ac.uk/pdbsum/3kbr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3kbr ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3kbr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3kbr OCA], [http://pdbe.org/3kbr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3kbr RCSB], [http://www.ebi.ac.uk/pdbsum/3kbr PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3kbr ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PHEC_PSEAE PHEC_PSEAE]] Forms alternative pathway for phenylalanine biosynthesis. Can catalyze two reactions: prephenate dehydratase and arogenate dehydratase. May have a role in chemotaxis or transport.  
[https://www.uniprot.org/uniprot/PHEC_PSEAE PHEC_PSEAE] Forms alternative pathway for phenylalanine biosynthesis. Can catalyze two reactions: prephenate dehydratase and arogenate dehydratase. May have a role in chemotaxis or transport.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kb/3kbr_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kb/3kbr_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Buck, K]]
[[Category: Large Structures]]
[[Category: Joachimiak, A]]
[[Category: Pseudomonas aeruginosa]]
[[Category: Structural genomic]]
[[Category: Buck K]]
[[Category: Marshall, N]]
[[Category: Joachimiak A]]
[[Category: Tan, K]]
[[Category: Marshall N]]
[[Category: Amino-acid biosynthesis]]
[[Category: Tan K]]
[[Category: Aromatic amino acid biosynthesis]]
[[Category: Cyclohexadienyl dehydratase precursor]]
[[Category: Lyase]]
[[Category: Mcsg]]
[[Category: Multifunctional enzyme]]
[[Category: Phenylalanine biosynthesis]]
[[Category: PSI, Protein structure initiative]]
[[Category: Pseudomonas aeruginosa pa01]]

Latest revision as of 08:00, 9 October 2024

The crystal structure of cyclohexadienyl dehydratase precursor from Pseudomonas aeruginosa PA01

3kbr, resolution 1.66Å

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