6eub: Difference between revisions

<StructureSection load='6eub' size='340' side='right'caption='[[6eub]], [[Resolution|resolution]] 2.30&Aring;' scene=''>

<table><tr><td colspan='2'>[[6eub]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6EUB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6EUB FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=1PE:PENTAETHYLENE+GLYCOL'>1PE</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6eub FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6eub OCA], [https://pdbe.org/6eub PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6eub RCSB], [https://www.ebi.ac.uk/pdbsum/6eub PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6eub ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/ANGL4_HUMAN ANGL4_HUMAN] Protein with hypoxia-induced expression in endothelial cells. May act as a regulator of angiogenesis and modulate tumorigenesis. Inhibits proliferation, migration, and tubule formation of endothelial cells and reduces vascular leakage. May exert a protective function on endothelial cells through an endocrine action. It is directly involved in regulating glucose homeostasis, lipid metabolism, and insulin sensitivity. In response to hypoxia, the unprocessed form of the protein accumulates in the subendothelial extracellular matrix (ECM). The matrix-associated and immobilized unprocessed form limits the formation of actin stress fibers and focal contacts in the adhering endothelial cells and inhibits their adhesion. It also decreases motility of endothelial cells and inhibits the sprouting and tube formation (By similarity).<ref>PMID:12015030</ref> <ref>PMID:14583458</ref>  

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Alanen HI]]

[[Category: Biterova EI]]

[[Category: Esmaeeli M]]

[[Category: Ruddock LW]]

[[Category: Saaranen M]]