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==Ligand binding domain (LBD) of the p. aeruginosa histamine receptor TlpQ==
==Ligand binding domain (LBD) of the p. aeruginosa histamine receptor TlpQ==
<StructureSection load='6fu4' size='340' side='right' caption='[[6fu4]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
<StructureSection load='6fu4' size='340' side='right'caption='[[6fu4]], [[Resolution|resolution]] 2.45&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6fu4]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/Pseae Pseae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FU4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6FU4 FirstGlance]. <br>
<table><tr><td colspan='2'>[[6fu4]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa_PAO1 Pseudomonas aeruginosa PAO1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6FU4 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6FU4 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HSM:HISTAMINE'>HSM</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.45&#8491;</td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HSM:HISTAMINE'>HSM</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PA2654 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=208964 PSEAE])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6fu4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fu4 OCA], [https://pdbe.org/6fu4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6fu4 RCSB], [https://www.ebi.ac.uk/pdbsum/6fu4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6fu4 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6fu4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6fu4 OCA], [http://pdbe.org/6fu4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6fu4 RCSB], [http://www.ebi.ac.uk/pdbsum/6fu4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6fu4 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[https://www.uniprot.org/uniprot/TLPQ_PSEAE TLPQ_PSEAE] Chemotactic-signal transducers respond to changes in the concentration of attractants and repellents in the environment, transduce a signal from the outside to the inside of the cell, and facilitate sensory adaptation through the variation of the level of methylation. TlpQ is a chemoreceptor that binds and mediates chemotaxis to histamine, a key biological signaling molecule. It binds histamine with high affinity, which permits responses to very low histamine concentrations (PubMed:30425146). Chemotaxis to histamine may play a role in the virulence of P.aeruginosa by recruiting cells at the infection site and consequently modulating the expression of quorum-sensing-dependent virulence genes (Probable). TlpQ also binds and mediates chemotaxis to polyamines such as putrescine, spermidine, cadaverine, agmatine and ethylenediamine (PubMed:30425146). In addition, binds the quorum-sensing signal autoinducer 2 (AI-2), thus inducing chemotaxis toward AI-2 and biofilm formation (PubMed:33097715).<ref>PMID:30425146</ref> <ref>PMID:33097715</ref> <ref>PMID:30425146</ref>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Pseae]]
[[Category: Large Structures]]
[[Category: Conejero-Muriel, M]]
[[Category: Pseudomonas aeruginosa PAO1]]
[[Category: Corral-Lugo, A]]
[[Category: Conejero-Muriel M]]
[[Category: Gavira, J A]]
[[Category: Corral-Lugo A]]
[[Category: Jimenez, H Silva]]
[[Category: Gavira JA]]
[[Category: Krell, T]]
[[Category: Krell T]]
[[Category: Martin-Mora, D]]
[[Category: Martin-Mora D]]
[[Category: Matilla, M A]]
[[Category: Matilla MA]]
[[Category: Torres, N Mesa]]
[[Category: Mesa Torres N]]
[[Category: Chemoreceptor]]
[[Category: Silva Jimenez H]]
[[Category: Chemotaxis]]
[[Category: Histamine]]
[[Category: Pseudomonas aeruginosa]]
[[Category: Signaling protein]]
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