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| <StructureSection load='7jtl' size='340' side='right'caption='[[7jtl]], [[Resolution|resolution]] 2.04Å' scene=''> | | <StructureSection load='7jtl' size='340' side='right'caption='[[7jtl]], [[Resolution|resolution]] 2.04Å' scene=''> |
| == Structural highlights == | | == Structural highlights == |
| <table><tr><td colspan='2'>[[7jtl]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/2019-ncov 2019-ncov]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JTL OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=7JTL FirstGlance]. <br> | | <table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7JTL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7JTL FirstGlance]. <br> |
| </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7jtl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jtl OCA], [http://pdbe.org/7jtl PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7jtl RCSB], [http://www.ebi.ac.uk/pdbsum/7jtl PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7jtl ProSAT]</span></td></tr> | | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.04Å</td></tr> |
| | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7jtl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7jtl OCA], [https://pdbe.org/7jtl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7jtl RCSB], [https://www.ebi.ac.uk/pdbsum/7jtl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7jtl ProSAT]</span></td></tr> |
| </table> | | </table> |
| == Function ==
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| [[http://www.uniprot.org/uniprot/NS8_SARS2 NS8_SARS2]] May play a role in host-virus interaction.
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| <div style="background-color:#fffaf0;">
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| == Publication Abstract from PubMed ==
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| The molecular basis for the severity and rapid spread of the COVID-19 disease caused by SARS-CoV-2 is largely unknown. ORF8 is a rapidly evolving accessory protein that has been proposed to interfere with immune responses. The crystal structure of SARS-CoV-2 ORF8 was determined at 2.04 A resolution by x-ray crystallography. The structure reveals a ~60 residue core similar to SARS-CoV ORF7a with the addition of two dimerization interfaces unique to SARS-CoV-2 ORF8. A covalent disulfide-linked dimer is formed through an N-terminal sequence specific to SARS-CoV-2, while a separate non-covalent interface is formed by another SARS-CoV-2-specific sequence, 73 YIDI 76 . Together the presence of these interfaces shows how SARS-CoV-2 ORF8 can form unique large-scale assemblies not possible for SARS-CoV, potentially mediating unique immune suppression and evasion activities.
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| Structure of SARS-CoV-2 ORF8, a rapidly evolving coronavirus protein implicated in immune evasion.,Flower TG, Buffalo CZ, Hooy RM, Allaire M, Ren X, Hurley JH bioRxiv. 2020 Aug 27. doi: 10.1101/2020.08.27.270637. PMID:32869027<ref>PMID:32869027</ref>
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| From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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| </div>
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| <div class="pdbe-citations 7jtl" style="background-color:#fffaf0;"></div>
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| ==See Also== | | ==See Also== |
| *[[Nonstructural protein 3D structures|Nonstructural protein 3D structures]] | | *[[Nonstructural protein 3D structures|Nonstructural protein 3D structures]] |
| == References ==
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| <references/>
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| __TOC__ | | __TOC__ |
| </StructureSection> | | </StructureSection> |
| [[Category: 2019-ncov]]
| |
| [[Category: Large Structures]] | | [[Category: Large Structures]] |
| [[Category: Allaire, M]] | | [[Category: Allaire M]] |
| [[Category: Buffalo, C Z]] | | [[Category: Buffalo CZ]] |
| [[Category: Flower, T G]] | | [[Category: Flower TG]] |
| [[Category: Hooy, R M]] | | [[Category: Hooy RM]] |
| [[Category: Hurley, J H]] | | [[Category: Hurley JH]] |
| [[Category: Ren, X]] | | [[Category: Ren X]] |
| [[Category: Accessory protein]]
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| [[Category: Coronavirus]]
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| [[Category: Covid-19]]
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| [[Category: Host-factor restriction]]
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| [[Category: Immune evasion]]
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| [[Category: Mhc-i]]
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| [[Category: Open reading frame 8]]
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| [[Category: Rna virus]]
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| [[Category: Sars-cov-2]]
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| [[Category: Sars2]]
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| [[Category: Viral protein]]
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