7kx0: Difference between revisions
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[https://www.uniprot.org/uniprot/CD70_HUMAN CD70_HUMAN] Combined immunodeficiency due to CD70 deficiency. The disease is caused by variants affecting the gene represented in this entry. | [https://www.uniprot.org/uniprot/CD70_HUMAN CD70_HUMAN] Combined immunodeficiency due to CD70 deficiency. The disease is caused by variants affecting the gene represented in this entry. | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/CD70_HUMAN CD70_HUMAN] | [https://www.uniprot.org/uniprot/CD70_HUMAN CD70_HUMAN] Expressed at the plasma membrane of B cells, it is the ligand of the CD27 receptor which is specifically expressed at the surface of T cells (PubMed:28011863, PubMed:28011864, PubMed:8387892). The CD70-CD27 signaling pathway mediates antigen-specific T cell activation and expansion which in turn provides immune surveillance of B cells (PubMed:28011863, PubMed:28011864).<ref>PMID:28011863</ref> <ref>PMID:28011864</ref> <ref>PMID:8387892</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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<div class="pdbe-citations 7kx0" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 7kx0" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Tumor necrosis factor ligand superfamily 3D structures|Tumor necrosis factor ligand superfamily 3D structures]] | |||
*[[Tumor necrosis factor receptor 3D structures|Tumor necrosis factor receptor 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
