7rhr: Difference between revisions

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<StructureSection load='7rhr' size='340' side='right'caption='[[7rhr]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
<StructureSection load='7rhr' size='340' side='right'caption='[[7rhr]], [[Resolution|resolution]] 3.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[7rhr]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RHR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RHR FirstGlance]. <br>
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7RHR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7RHR FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[7rhq|7rhq]]</div></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rhr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rhr OCA], [https://pdbe.org/7rhr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rhr RCSB], [https://www.ebi.ac.uk/pdbsum/7rhr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rhr ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7rhr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7rhr OCA], [https://pdbe.org/7rhr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7rhr RCSB], [https://www.ebi.ac.uk/pdbsum/7rhr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7rhr ProSAT]</span></td></tr>
</table>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The dually lipidated Sonic hedgehog (SHH) morphogen signals through the tumor suppressor membrane protein Patched1 (PTCH1) to activate the Hedgehog pathway, which is fundamental in development and cancer. SHH engagement with PTCH1 requires the GAS1 coreceptor, but the mechanism is unknown. We demonstrate a unique role for GAS1, catalyzing SHH-PTCH1 complex assembly in vertebrate cells by direct SHH transfer from the extracellular SCUBE2 carrier to PTCH1. Structure of the GAS1-SHH-PTCH1 transition state identifies how GAS1 recognizes the SHH palmitate and cholesterol modifications in modular fashion and how it facilitates lipid-dependent SHH handoff to PTCH1. Structure-guided experiments elucidate SHH movement from SCUBE2 to PTCH1, explain disease mutations, and demonstrate that SHH-induced PTCH1 dimerization causes its internalization from the cell surface. These results define how the signaling-competent SHH-PTCH1 complex assembles, the key step triggering the Hedgehog pathway, and provide a paradigm for understanding morphogen reception and its regulation.
Structural basis for catalyzed assembly of the Sonic hedgehog-Patched1 signaling complex.,Huang P, Wierbowski BM, Lian T, Chan C, Garcia-Linares S, Jiang J, Salic A Dev Cell. 2022 Feb 25. pii: S1534-5807(22)00074-0. doi:, 10.1016/j.devcel.2022.02.008. PMID:35231446<ref>PMID:35231446</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 7rhr" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Huang, P]]
[[Category: Huang P]]
[[Category: Jiang, J]]
[[Category: Jiang J]]
[[Category: Lian, T]]
[[Category: Lian T]]
[[Category: Salic, A]]
[[Category: Salic A]]
[[Category: Membrane protein]]
[[Category: Patched]]

Latest revision as of 09:34, 9 October 2024

Cryo-EM structure of Xenopus Patched-1 in nanodisc

7rhr, resolution 3.00Å

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