8fso: Difference between revisions

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'''Unreleased structure'''


The entry 8fso is ON HOLD  until Paper Publication
==Crystal structure of integrin beta-6 tail bound to the FERM-folded talin head domain==
 
<StructureSection load='8fso' size='340' side='right'caption='[[8fso]], [[Resolution|resolution]] 2.33&Aring;' scene=''>
Authors: Wu, J., Gao, T.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8fso]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8FSO OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8FSO FirstGlance]. <br>
Description: Crystal structure of integrin beta-6 tail bound to the FERM-folded talin head domain
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.33&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8fso FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8fso OCA], [https://pdbe.org/8fso PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8fso RCSB], [https://www.ebi.ac.uk/pdbsum/8fso PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8fso ProSAT]</span></td></tr>
[[Category: Gao, T]]
</table>
[[Category: Wu, J]]
== Function ==
[https://www.uniprot.org/uniprot/TLN1_MOUSE TLN1_MOUSE] Probably involved in connections of major cytoskeletal structures to the plasma membrane. High molecular weight cytoskeletal protein concentrated at regions of cell-substratum contact and, in lymphocytes, at cell-cell contacts.[https://www.uniprot.org/uniprot/ITB6_MOUSE ITB6_MOUSE] Integrin alpha-V:beta-6 (ITGAV:ITGB6) is a receptor for fibronectin and cytotactin (By similarity). It recognizes the sequence R-G-D in its ligands (PubMed:10025398). ITGAV:ITGB6 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (By similarity). Integrin alpha-V:beta-6 (ITGAV:ITGB6) mediates R-G-D-dependent release of transforming growth factor beta-1 (TGF-beta-1) from regulatory Latency-associated peptide (LAP), thereby playing a key role in TGF-beta-1 activation (PubMed:10025398).[UniProtKB:P18564]<ref>PMID:10025398</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Gao T]]
[[Category: Wu J]]
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