8uf8: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

The entry ~~8uf8 is ON HOLD~~ ~~until Paper Publication~~

==Cryo-EM structure of alpha-Klotho==

~~Authors~~:

== Structural highlights ==

<table><tr><td colspan='2'>[[8uf8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8UF8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8UF8 FirstGlance]. <br>

~~Description~~:

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 6.5Å</td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8uf8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8uf8 OCA], [https://pdbe.org/8uf8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8uf8 RCSB], [https://www.ebi.ac.uk/pdbsum/8uf8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8uf8 ProSAT]</span></td></tr>

</table>

== Disease ==

[https://www.uniprot.org/uniprot/KLOT_HUMAN KLOT_HUMAN] Familial tumoral calcinosis. The disease is caused by mutations affecting the gene represented in this entry.

== Function ==

[https://www.uniprot.org/uniprot/KLOT_HUMAN KLOT_HUMAN] May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1 (By similarity). The Klotho peptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signaling.

__TOC__

</StructureSection>

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Gakhar L]]

[[Category: Huang CL]]

[[Category: Mohammad A]]

[[Category: Schnicker NJ]]

[[Category: Xu Z]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 8uf8 is ON HOLD  until Paper Publication
+==Cryo-EM structure of alpha-Klotho==
+<StructureSection load='8uf8' size='340' side='right'caption='[[8uf8]], [[Resolution|resolution]] 6.50&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8uf8]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8UF8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8UF8 FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 6.5&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8uf8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8uf8 OCA], [https://pdbe.org/8uf8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8uf8 RCSB], [https://www.ebi.ac.uk/pdbsum/8uf8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8uf8 ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/KLOT_HUMAN KLOT_HUMAN] Familial tumoral calcinosis. The disease is caused by mutations affecting the gene represented in this entry.
+== Function ==
+[https://www.uniprot.org/uniprot/KLOT_HUMAN KLOT_HUMAN] May have weak glycosidase activity towards glucuronylated steroids. However, it lacks essential active site Glu residues at positions 239 and 872, suggesting it may be inactive as a glycosidase in vivo. May be involved in the regulation of calcium and phosphorus homeostasis by inhibiting the synthesis of active vitamin D (By similarity). Essential factor for the specific interaction between FGF23 and FGFR1 (By similarity).  The Klotho peptide generated by cleavage of the membrane-bound isoform may be an anti-aging circulating hormone which would extend life span by inhibiting insulin/IGF1 signaling.
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Gakhar L]]
+[[Category: Huang CL]]
+[[Category: Mohammad A]]
+[[Category: Schnicker NJ]]
+[[Category: Xu Z]]