9g8o: Difference between revisions

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'''Unreleased structure'''


The entry 9g8o is ON HOLD  until Paper Publication
==human 40S ribosome bound by a SKI238-exosome complex==
 
<StructureSection load='9g8o' size='340' side='right'caption='[[9g8o]], [[Resolution|resolution]] 3.40&Aring;' scene=''>
Authors: Koegel, A., Keidel, A., Loukeri, M.J., Kuhn, C.C., Langer, L.M., Schaefer, I.B., Conti, E.
== Structural highlights ==
 
<table><tr><td colspan='2'>[[9g8o]] is a 11 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9G8O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9G8O FirstGlance]. <br>
Description: human 40S ribosome bound by a SKI238-exosome complex
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.4&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9g8o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9g8o OCA], [https://pdbe.org/9g8o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9g8o RCSB], [https://www.ebi.ac.uk/pdbsum/9g8o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9g8o ProSAT]</span></td></tr>
[[Category: Koegel, A]]
</table>
[[Category: Loukeri, M.J]]
== Disease ==
[[Category: Schaefer, I.B]]
[https://www.uniprot.org/uniprot/SKI3_HUMAN SKI3_HUMAN] Syndromic diarrhea. The disease is caused by variants affecting the gene represented in this entry.
[[Category: Langer, L.M]]
== Function ==
[[Category: Kuhn, C.C]]
[https://www.uniprot.org/uniprot/SKI3_HUMAN SKI3_HUMAN] Component of the SKI complex, a multiprotein complex that assists the RNA-degrading exosome during the mRNA decay and quality-control pathways (PubMed:16024656, PubMed:32006463, PubMed:35120588). The SKI complex catalyzes mRNA extraction from 80S ribosomal complexes in the 3'-5' direction and channels mRNA to the cytosolic exosome for degradation (PubMed:32006463, PubMed:35120588). SKI-mediated extraction of mRNA from stalled ribosomes allow binding of the Pelota-HBS1L complex and subsequent ribosome disassembly by ABCE1 for ribosome recycling (PubMed:32006463). In the nucleus, the SKI complex associates with transcriptionally active genes in a manner dependent on PAF1 complex (PAF1C) (PubMed:16024656).<ref>PMID:16024656</ref> <ref>PMID:32006463</ref> <ref>PMID:35120588</ref>
[[Category: Keidel, A]]
== References ==
[[Category: Conti, E]]
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Conti E]]
[[Category: Keidel A]]
[[Category: Koegel A]]
[[Category: Kuhn CC]]
[[Category: Langer LM]]
[[Category: Loukeri MJ]]
[[Category: Schaefer IB]]

Latest revision as of 04:20, 17 October 2024

human 40S ribosome bound by a SKI238-exosome complex

9g8o, resolution 3.40Å

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