9jdv: Difference between revisions

Latest revision as of 04:21, 17 October 2024

Human URAT1 bound with Uric acid

Structural highlights

9jdv is a 1 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:	Electron Microscopy, Resolution 3.32Å
Ligands:	URC
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

S22AC_HUMAN Hereditary renal hypouricemia. The disease is caused by variants affecting the gene represented in this entry.

Function

S22AC_HUMAN Electroneutral antiporter that translocates urate across the apical membrane of proximal tubular cells in exchange for monovalent organic or inorganic anions (PubMed:12024214, PubMed:22194875, PubMed:35144162, PubMed:35462902). Involved in renal reabsorption of urate and helps maintaining blood levels of uric acid (PubMed:12024214, PubMed:22194875). Mediates urate uptake by an exchange with organic anions such as (S)-lactate and nicotinate, and inorganic anion Cl(-) (PubMed:12024214). Other inorganic anions such as Br(-), I(-) and NO3(-) may also act as counteranions that exchange for urate (PubMed:12024214). Also mediates orotate tubular uptake coupled with nicotinate efflux and to a lesser extent with lactate efflux, therefore displaying a potential role in orotate renal reabsorption (PubMed:21350910). Orotate transport is Cl(-)-dependent (PubMed:21350910).^[1] ^[2] ^[3] ^[4] ^[5]

References

↑ Enomoto A, Kimura H, Chairoungdua A, Shigeta Y, Jutabha P, Cha SH, Hosoyamada M, Takeda M, Sekine T, Igarashi T, Matsuo H, Kikuchi Y, Oda T, Ichida K, Hosoya T, Shimokata K, Niwa T, Kanai Y, Endou H. Molecular identification of a renal urate anion exchanger that regulates blood urate levels. Nature. 2002 May 23;417(6887):447-52. PMID:12024214 doi:10.1038/nature742
↑ Miura D, Anzai N, Jutabha P, Chanluang S, He X, Fukutomi T, Endou H. Human urate transporter 1 (hURAT1) mediates the transport of orotate. J Physiol Sci. 2011 May;61(3):253-7. PMID:21350910 doi:10.1007/s12576-011-0136-0
↑ Tasic V, Hynes AM, Kitamura K, Cheong HI, Lozanovski VJ, Gucev Z, Jutabha P, Anzai N, Sayer JA. Clinical and functional characterization of URAT1 variants. PLoS One. 2011;6(12):e28641. PMID:22194875 doi:10.1371/journal.pone.0028641
↑ Shinoda Y, Yamashiro T, Hosooka A, Yasujima T, Yuasa H. Functional characterization of human organic anion transporter 10 (OAT10/SLC22A13) as an orotate transporter. Drug Metab Pharmacokinet. 2022 Apr;43:100443. PMID:35144162 doi:10.1016/j.dmpk.2021.100443
↑ Toyoda Y, Kawamura Y, Nakayama A, Morimoto K, Shimizu S, Tanahashi Y, Tamura T, Kondo T, Kato Y, Ichida K, Suzuki H, Shinomiya N, Kobayashi Y, Takada T, Matsuo H. OAT10/SLC22A13 Acts as a Renal Urate Re-Absorber: Clinico-Genetic and Functional Analyses With Pharmacological Impacts. Front Pharmacol. 2022 Apr 6;13:842717. PMID:35462902 doi:10.3389/fphar.2022.842717

Proteopedia Page Contributors and Editors (what is this?)

OCA

[1] Enomoto A, Kimura H, Chairoungdua A, Shigeta Y, Jutabha P, Cha SH, Hosoyamada M, Takeda M, Sekine T, Igarashi T, Matsuo H, Kikuchi Y, Oda T, Ichida K, Hosoya T, Shimokata K, Niwa T, Kanai Y, Endou H. Molecular identification of a renal urate anion exchanger that regulates blood urate levels. Nature. 2002 May 23;417(6887):447-52. PMID:12024214 doi:10.1038/nature742

[2] Miura D, Anzai N, Jutabha P, Chanluang S, He X, Fukutomi T, Endou H. Human urate transporter 1 (hURAT1) mediates the transport of orotate. J Physiol Sci. 2011 May;61(3):253-7. PMID:21350910 doi:10.1007/s12576-011-0136-0

[3] Tasic V, Hynes AM, Kitamura K, Cheong HI, Lozanovski VJ, Gucev Z, Jutabha P, Anzai N, Sayer JA. Clinical and functional characterization of URAT1 variants. PLoS One. 2011;6(12):e28641. PMID:22194875 doi:10.1371/journal.pone.0028641

[4] Shinoda Y, Yamashiro T, Hosooka A, Yasujima T, Yuasa H. Functional characterization of human organic anion transporter 10 (OAT10/SLC22A13) as an orotate transporter. Drug Metab Pharmacokinet. 2022 Apr;43:100443. PMID:35144162 doi:10.1016/j.dmpk.2021.100443

[5] Toyoda Y, Kawamura Y, Nakayama A, Morimoto K, Shimizu S, Tanahashi Y, Tamura T, Kondo T, Kato Y, Ichida K, Suzuki H, Shinomiya N, Kobayashi Y, Takada T, Matsuo H. OAT10/SLC22A13 Acts as a Renal Urate Re-Absorber: Clinico-Genetic and Functional Analyses With Pharmacological Impacts. Front Pharmacol. 2022 Apr 6;13:842717. PMID:35462902 doi:10.3389/fphar.2022.842717

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[5]

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 9jdv is ON HOLD  until Paper Publication
+==Human URAT1 bound with Uric acid==
+<StructureSection load='9jdv' size='340' side='right'caption='[[9jdv]], [[Resolution|resolution]] 3.32&Aring;' scene=''>
-Authors:
+== Structural highlights ==
+<table><tr><td colspan='2'>[[9jdv]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9JDV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9JDV FirstGlance]. <br>
-Description:
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.32&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=URC:URIC+ACID'>URC</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9jdv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9jdv OCA], [https://pdbe.org/9jdv PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9jdv RCSB], [https://www.ebi.ac.uk/pdbsum/9jdv PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9jdv ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/S22AC_HUMAN S22AC_HUMAN] Hereditary renal hypouricemia. The disease is caused by variants affecting the gene represented in this entry.
+== Function ==
+[https://www.uniprot.org/uniprot/S22AC_HUMAN S22AC_HUMAN] Electroneutral antiporter that translocates urate across the apical membrane of proximal tubular cells in exchange for monovalent organic or inorganic anions (PubMed:12024214, PubMed:22194875, PubMed:35144162, PubMed:35462902). Involved in renal reabsorption of urate and helps maintaining blood levels of uric acid (PubMed:12024214, PubMed:22194875). Mediates urate uptake by an exchange with organic anions such as (S)-lactate and nicotinate, and inorganic anion Cl(-) (PubMed:12024214). Other inorganic anions such as Br(-), I(-) and NO3(-) may also act as counteranions that exchange for urate (PubMed:12024214). Also mediates orotate tubular uptake coupled with nicotinate efflux and to a lesser extent with lactate efflux, therefore displaying a potential role in orotate renal reabsorption (PubMed:21350910). Orotate transport is Cl(-)-dependent (PubMed:21350910).<ref>PMID:12024214</ref> <ref>PMID:21350910</ref> <ref>PMID:22194875</ref> <ref>PMID:35144162</ref> <ref>PMID:35462902</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Wu C]]
+[[Category: Xu HE]]

9jdv: Difference between revisions

Latest revision as of 04:21, 17 October 2024

Human URAT1 bound with Uric acid

Structural highlights

Disease

Function

References

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