6bit: Difference between revisions

<table><tr><td colspan='2'>[[6bit]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6BIT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6BIT FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.191&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PCA:PYROGLUTAMIC+ACID'>PCA</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6bit FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6bit OCA], [https://pdbe.org/6bit PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6bit RCSB], [https://www.ebi.ac.uk/pdbsum/6bit PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6bit ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/SHPS1_HUMAN SHPS1_HUMAN] Immunoglobulin-like cell surface receptor for CD47. Acts as docking protein and induces translocation of PTPN6, PTPN11 and other binding partners from the cytosol to the plasma membrane. Supports adhesion of cerebellar neurons, neurite outgrowth and glial cell attachment. May play a key role in intracellular signaling during synaptogenesis and in synaptic function (By similarity). Involved in the negative regulation of receptor tyrosine kinase-coupled cellular responses induced by cell adhesion, growth factors or insulin. Mediates negative regulation of phagocytosis, mast cell activation and dendritic cell activation. CD47 binding prevents maturation of immature dendritic cells and inhibits cytokine production by mature dendritic cells.<ref>PMID:10469599</ref> <ref>PMID:11509594</ref>  

[[Category: Homo sapiens]]

[[Category: Flavell RA]]

[[Category: George BM]]

[[Category: Herndler-Brandstetter D]]

[[Category: Lietzenmayer M]]

[[Category: McCarty A]]

[[Category: McKenna KM]]

[[Category: Naik TJ]]

[[Category: Ring AM]]

[[Category: Ring NG]]

[[Category: Shan L]]

[[Category: Volkmer JP]]

[[Category: Weiskopf K]]

[[Category: Weissman IL]]

[[Category: Zheng Y]]