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==Three dimensional structure of human carbonic anhydrase IX in complex with sulfonamide==
==Three dimensional structure of human carbonic anhydrase IX in complex with sulfonamide==
<StructureSection load='6g98' size='340' side='right' caption='[[6g98]], [[Resolution|resolution]] 2.47&Aring;' scene=''>
<StructureSection load='6g98' size='340' side='right'caption='[[6g98]], [[Resolution|resolution]] 2.47&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6g98]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G98 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6G98 FirstGlance]. <br>
<table><tr><td colspan='2'>[[6g98]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6G98 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6G98 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ER5:4-[2-[3-(cyclododecylamino)-2,5,6-tris(fluoranyl)-4-sulfamoyl-phenyl]sulfanylethyl]benzoic+acid'>ER5</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.47&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ER5:4-[2-[3-(cyclododecylamino)-2,5,6-tris(fluoranyl)-4-sulfamoyl-phenyl]sulfanylethyl]benzoic+acid'>ER5</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6g98 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g98 OCA], [http://pdbe.org/6g98 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6g98 RCSB], [http://www.ebi.ac.uk/pdbsum/6g98 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6g98 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6g98 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6g98 OCA], [https://pdbe.org/6g98 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6g98 RCSB], [https://www.ebi.ac.uk/pdbsum/6g98 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6g98 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[[http://www.uniprot.org/uniprot/CAH9_HUMAN CAH9_HUMAN]] Reversible hydration of carbon dioxide. Participates in pH regulation. May be involved in the control of cell proliferation and transformation. Appears to be a novel specific biomarker for a cervical neoplasia.<ref>PMID:18703501</ref> 
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 6g98" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 6g98" style="background-color:#fffaf0;"></div>
==See Also==
*[[Carbonic anhydrase 3D structures|Carbonic anhydrase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Carbonate dehydratase]]
[[Category: Homo sapiens]]
[[Category: Leitans, J]]
[[Category: Large Structures]]
[[Category: Tars, K]]
[[Category: Leitans J]]
[[Category: Lyase]]
[[Category: Tars K]]

Latest revision as of 07:58, 17 October 2024

Three dimensional structure of human carbonic anhydrase IX in complex with sulfonamide

6g98, resolution 2.47Å

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