6hav: Difference between revisions

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<StructureSection load='6hav' size='340' side='right'caption='[[6hav]], [[Resolution|resolution]] 1.06&Aring;' scene=''>
<StructureSection load='6hav' size='340' side='right'caption='[[6hav]], [[Resolution|resolution]] 1.06&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[6hav]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HAV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HAV FirstGlance]. <br>
<table><tr><td colspan='2'>[[6hav]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanococcus_aeolicus_Nankai-3 Methanococcus aeolicus Nankai-3]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HAV OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6HAV FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=E4M:1-{4-[(6S,6aR,7R)-3-amino-6,7-dimethyl-1-oxo-1,2,5,6,6a,7-hexahydro-8H-imidazo[1,5-f]pteridin-10-ium-8-yl]phenyl}-1-deoxy-5-O-{5-O-[(S)-{[(1S)-1,3-dicarboxypropyl]oxy}(hydroxy)phosphoryl]-alpha-D-ribofuranosyl}-D-ribitol'>E4M</scene>, <scene name='pdbligand=FE9:IRON-GUANYLYL+PYRIDINOL+COFACTOR'>FE9</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.06&#8491;</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/5,10-methenyltetrahydromethanopterin_hydrogenase 5,10-methenyltetrahydromethanopterin hydrogenase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.12.98.2 1.12.98.2] </span></td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=E4M:(2S)-2-[[(2R,3S,4R,5S)-5-[(2R,3S,4S)-5-[4-[(6S,6aR,7R)-3-azanyl-6,7-dimethyl-1-oxo-5,6,6a,7-tetrahydro-2H-imidazo[1,5-f]pteridin-10-ium-8-yl]phenyl]-2,3,4-trihydroxy-pentoxy]-3,4-dihydroxy-oxolan-2-yl]methoxy-hydroxy-phosphoryl]oxypentanedioic+acid'>E4M</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hav FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hav OCA], [http://pdbe.org/6hav PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hav RCSB], [http://www.ebi.ac.uk/pdbsum/6hav PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hav ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6hav FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hav OCA], [https://pdbe.org/6hav PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6hav RCSB], [https://www.ebi.ac.uk/pdbsum/6hav PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6hav ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/A6UVT1_META3 A6UVT1_META3]] Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.[HAMAP-Rule:MF_01090]  
[https://www.uniprot.org/uniprot/A6UVT1_META3 A6UVT1_META3] Catalyzes the reversible reduction of methenyl-H(4)MPT(+) to methylene-H(4)MPT.[HAMAP-Rule:MF_01090]
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: 5,10-methenyltetrahydromethanopterin hydrogenase]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Ataka, K]]
[[Category: Methanococcus aeolicus Nankai-3]]
[[Category: Bill, E]]
[[Category: Ataka K]]
[[Category: Ermler, U]]
[[Category: Bill E]]
[[Category: Hu, X]]
[[Category: Ermler U]]
[[Category: Huang, G]]
[[Category: Hu X]]
[[Category: Shima, S]]
[[Category: Huang G]]
[[Category: Wagner, T]]
[[Category: Shima S]]
[[Category: Wodrich, M D]]
[[Category: Wagner T]]
[[Category: Atomic resolution]]
[[Category: Wodrich MD]]
[[Category: C1-metabolism]]
[[Category: Catalytic cycle]]
[[Category: Conformational rearrangement]]
[[Category: Fe-guanylylpyridinol cofactor]]
[[Category: Hydride-transfer]]
[[Category: Methanogenesis]]
[[Category: Oxidoreductase]]
[[Category: Tetrahydromethanopterin]]

Latest revision as of 08:00, 17 October 2024

Crystal structure of [Fe]-hydrogenase (Hmd) from Methanococcus aeolicus in complex with FeGP and methenyl-tetrahydromethanopterin (close form A) at 1.06 A resolution

6hav, resolution 1.06Å

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